Peter C Fineran
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Explore the profile of Peter C Fineran including associated specialties, affiliations and a list of published articles.
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134
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5568
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Recent Articles
1.
Harding K, Malone L, Kyte N, Jackson S, Smith L, Fineran P
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39694477
The Chimalliviridae family of bacteriophages (phages) form a proteinaceous nucleus-like structure during infection of their bacterial hosts. This phage 'nucleus' compartmentalises phage DNA replication and transcription, and shields the phage...
2.
Wang X, Jowsey W, Cheung C, Smart C, Klaus H, Seeto N, et al.
Nat Commun
. 2024 Nov;
15(1):9791.
PMID: 39537607
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase. We hypothesise that...
3.
Warring S, Sisson H, Fineran P, Rabiey M
Microb Biotechnol
. 2024 Oct;
17(10):e70017.
PMID: 39364588
The efficiency of global crop production is under threat from microbial pathogens which is likely to be worsened by climate change. Major contributors to plant disease are Pseudomonas syringae (P....
4.
Repurposing an Endogenous CRISPR-Cas System to Generate and Study Subtle Mutations in Bacteriophages
Kamata K, Birkholz N, Ceelen M, Fagerlund R, Jackson S, Fineran P
CRISPR J
. 2024 Sep;
7(6):343-354.
PMID: 39347602
While bacteriophage applications benefit from effective phage engineering, selecting the desired genotype after subtle modifications remains challenging. Here, we describe a two-phase endogenous CRISPR-Cas-based phage engineering approach that enables selection...
5.
Birkholz N, Fineran P
Mol Cell
. 2024 Sep;
84(17):3172-3174.
PMID: 39241751
Deploying anti-CRISPR proteins is a potent strategy used by phages to inhibit bacterial CRISPR-Cas defense. In a new Nature paper, Trost et al. discover and characterize an exciting anti-CRISPR mechanism...
6.
Birkholz N, Kamata K, Feussner M, Wilkinson M, Cuba Samaniego C, Migur A, et al.
Nature
. 2024 Jul;
631(8021):670-677.
PMID: 38987591
In all organisms, regulation of gene expression must be adjusted to meet cellular requirements and frequently involves helix-turn-helix (HTH) domain proteins. For instance, in the arms race between bacteria and...
7.
Schwartz E, Bravo J, Ahsan M, Macias L, McCafferty C, Dangerfield T, et al.
Nat Commun
. 2024 Apr;
15(1):3324.
PMID: 38637512
CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction. Target RNA cleavage at regular intervals is...
8.
Sisson H, Jackson S, Fagerlund R, Warring S, Fineran P
Curr Opin Microbiol
. 2024 Feb;
78:102433.
PMID: 38350268
Our ability to control the growth of Gram-negative bacterial pathogens is challenged by rising antimicrobial resistance and requires new approaches. Endolysins are phage-derived enzymes that degrade peptidoglycan and therefore offer...
9.
Sisson H, Fagerlund R, Jackson S, Briers Y, Warring S, Fineran P
Appl Environ Microbiol
. 2024 Feb;
90(3):e0184623.
PMID: 38319087
Importance: The phytopathogen pv. () causes major impacts to kiwifruit horticulture, and the current control strategies are heavily reliant on copper and antibiotics. The environmental impact and increasing resistance to...
10.
Mayo-Munoz D, Pinilla-Redondo R, Camara-Wilpert S, Birkholz N, Fineran P
Nat Rev Genet
. 2024 Jan;
25(4):237-254.
PMID: 38291236
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial defences include CRISPR-Cas, restriction-modification and a...