Paul Nimmer
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Explore the profile of Paul Nimmer including associated specialties, affiliations and a list of published articles.
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14
Citations
1857
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Recent Articles
1.
Judd A, Bawa B, Buck W, Tao Z, Li Y, Mitten M, et al.
Sci Adv
. 2024 Oct;
10(40):eado7120.
PMID: 39365864
Overexpression of the antiapoptotic protein B-cell lymphoma-extra large (BCL-X) is associated with drug resistance and disease progression in numerous cancers. The compelling nature of this protein as a therapeutic target...
2.
Wang L, Doherty G, Judd A, Tao Z, Hansen T, Frey R, et al.
ACS Med Chem Lett
. 2020 Oct;
11(10):1829-1836.
PMID: 33062160
Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-X inhibitor that selectively and potently induces apoptosis in BCL-X-dependent tumor cells. This molecule was generated by re-engineering our...
3.
Stockmann H, Marin V, Nimmer P, Balut C, Davidson D, Richardson P, et al.
Chembiochem
. 2015 Nov;
17(2):150-4.
PMID: 26574896
Membrane-bound proteins are important pharmaceutical drug targets, yet few strategies exist for the identification of small-molecule-targeted membrane proteins in live-cell systems. By exploiting metabolic glycan engineering of cell membrane proteins,...
4.
Xiao Y, Nimmer P, Sheppard G, Bruncko M, Hessler P, Lu X, et al.
Mol Cancer Ther
. 2015 May;
14(8):1837-47.
PMID: 26013319
Hyperexpression of antiapoptotic BCL-2 family proteins allows cells to survive despite the receipt of signals that would ordinarily induce their deletion, a facet frequently exploited by tumors. Tumors addicted to...
5.
Bruncko M, Wang L, Sheppard G, Phillips D, Tahir S, Xue J, et al.
J Med Chem
. 2015 May;
58(9):4089.
PMID: 25933255
No abstract available.
6.
Leverson J, Phillips D, Mitten M, Boghaert E, Diaz D, Tahir S, et al.
Sci Transl Med
. 2015 Mar;
7(279):279ra40.
PMID: 25787766
The BCL-2/BCL-XL/BCL-W inhibitor ABT-263 (navitoclax) has shown promising clinical activity in lymphoid malignancies such as chronic lymphocytic leukemia. However, its efficacy in these settings is limited by thrombocytopenia caused by...
7.
Bruncko M, Wang L, Sheppard G, Phillips D, Tahir S, Xue J, et al.
J Med Chem
. 2015 Feb;
58(5):2180-94.
PMID: 25679114
Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progression and survival of multiple tumor types. Herein we report a series of MCL-1...
8.
Tao Z, Hasvold L, Wang L, Wang X, Petros A, Park C, et al.
ACS Med Chem Lett
. 2014 Oct;
5(10):1088-93.
PMID: 25313317
A-1155463, a highly potent and selective BCL-XL inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines...
9.
Chen J, Jin S, Abraham V, Huang X, Liu B, Mitten M, et al.
Mol Cancer Ther
. 2011 Sep;
10(12):2340-9.
PMID: 21914853
The ability of a cancer cell to avoid apoptosis is crucial to tumorigenesis and can also contribute to chemoresistance. The Bcl-2 family of prosurvival proteins (Bcl-2, Bcl-X(L), Bcl-w, Mcl-1, and...
10.
Petros A, Huth J, Oost T, Park C, Ding H, Wang X, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(22):6587-91.
PMID: 20870405
The Bcl-2 family of proteins plays a major role in the regulation of apoptosis, or programmed cell death. Overexpression of the anti-apoptotic members of this family (Bcl-2, Bcl-x(L), and Mcl-1)...