Paul Nimmer
Overview
Explore the profile of Paul Nimmer including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1857
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0
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Recent Articles
11.
Park C, Bruncko M, Adickes J, Bauch J, Ding H, Kunzer A, et al.
J Med Chem
. 2008 Oct;
51(21):6902-15.
PMID: 18841882
Overexpression of prosurvival proteins such as Bcl-2 and Bcl-X L has been correlated with tumorigenesis and resistance to chemotherapy, and thus, the development of antagonists of these proteins may provide...
12.
Tse C, Shoemaker A, Adickes J, Anderson M, Chen J, Jin S, et al.
Cancer Res
. 2008 May;
68(9):3421-8.
PMID: 18451170
Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule...
13.
Shoemaker A, Oleksijew A, Bauch J, Belli B, Borre T, Bruncko M, et al.
Cancer Res
. 2006 Sep;
66(17):8731-9.
PMID: 16951189
Inhibition of the prosurvival members of the Bcl-2 family of proteins represents an attractive strategy for the treatment of cancer. We have previously reported the activity of ABT-737, a potent...
14.
Zhang H, Nimmer P, Rosenberg S, Ng S, Joseph M
Anal Biochem
. 2002 Jul;
307(1):70-5.
PMID: 12137781
Antiapoptotic protein Bcl-x(L) has been demonstrated to play a very important role in a variety of diseases such as cancer. Its biological function can be inhibited by proapoptotic proteins such...