Paul N Epstein
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Explore the profile of Paul N Epstein including associated specialties, affiliations and a list of published articles.
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69
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2218
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Recent Articles
11.
Wu H, Kong L, Tan Y, Epstein P, Zeng J, Gu J, et al.
Diabetologia
. 2016 Apr;
59(7):1558-1568.
PMID: 27115417
Aims/hypothesis: Diabetic nephropathy is the leading cause of end-stage renal disease. Previously we reported that C66, a novel analogue of curcumin with a very high bioavailability, ameliorated diabetic nephropathy in...
12.
Xu J, Zheng S, Kralik P, Krishnan L, Huang H, Hoying J, et al.
Int J Biol Sci
. 2016 Feb;
12(2):210-8.
PMID: 26884718
The effect of diabetes in vivo has not been examined on isolated podocytes. To achieve this, GFP was expressed constitutively in podocytes of PGFP transgenic mice which were bred to...
13.
Zheng S, Coventry S, Cai L, Powell D, Jala V, Haribabu B, et al.
J Diabetes Res
. 2016 Jan;
2016:5362506.
PMID: 26798651
In diabetic nephropathy (DN) proinflammatory chemokines and leukocyte infiltration correlate with tubulointerstitial injury and declining renal function. The atypical chemokine receptor ACKR2 is a chemokine scavenger receptor which binds and...
14.
Barati M, Powell D, Kechavarzi B, Isaacs S, Zheng S, Epstein P, et al.
Cell Stress Chaperones
. 2015 Oct;
21(1):155-166.
PMID: 26483256
Regulation of the endoplasmic reticulum (ER) stress-response pathway during the course of diabetes specifically in renal tubules is unclear. Since tubule cell dysfunction is critical to progression of diabetic nephropathy,...
15.
Sun W, Miao X, Zhou S, Zhang L, Epstein P, Mellen N, et al.
J Mol Cell Cardiol
. 2014 May;
74:88-97.
PMID: 24819347
We have demonstrated that zinc supplementation provides cardiac protection from diabetes in mice, but its underlying mechanism remains unclear. Since zinc mimics the function of insulin, it may provide benefit...
16.
Yin X, Zhou S, Zheng Y, Tan Y, Kong M, Wang B, et al.
Toxicol Appl Pharmacol
. 2014 Mar;
277(1):58-66.
PMID: 24657099
Obstructive sleep apnea (OSA) causes chronic intermittent hypoxia (IH) to induce cardiovascular disease, which may be related to oxidative damage. Metallothionein (MT) has been extensively proved to be an endogenous...
17.
Sun W, Wang Y, Miao X, Wang Y, Zhang L, Xin Y, et al.
Free Radic Biol Med
. 2013 Dec;
68:22-34.
PMID: 24296248
Human epidemiological and animal studies have shown the beneficial effect of zinc supplementation on mitigating diabetic nephropathy. However, the mechanism by which zinc protects the kidney from diabetes remains unknown....
18.
Powell D, Kenagy D, Zheng S, Coventry S, Xu J, Cai L, et al.
Life Sci
. 2013 Jun;
93(7):257-64.
PMID: 23800643
Type 1 and Type 2 diabetic patients are at high risk of developing diabetic nephropathy (DN). Renal functional decline is gradual and there is high variability between patients, though the...
19.
Xu X, Kobayashi S, Chen K, Timm D, Volden P, Huang Y, et al.
J Biol Chem
. 2013 May;
288(25):18077-92.
PMID: 23658055
Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We addressed this question using mouse models...
20.
Wang J, Xu J, Wang Q, Brainard R, Watson L, Jones S, et al.
PLoS One
. 2013 Jan;
8(1):e53951.
PMID: 23308291
This study was designed to test whether reduced levels of cardiac fructose-2,6-bisphosphate (F-2,6-P(2)) exacerbates cardiac damage in response to pressure overload. F-2,6-P(2) is a positive regulator of the glycolytic enzyme...