Paul Mann
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Explore the profile of Paul Mann including associated specialties, affiliations and a list of published articles.
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19
Citations
261
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Recent Articles
11.
Lee S, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, et al.
Sci Transl Med
. 2016 Mar;
8(329):329ra32.
PMID: 26962156
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S....
12.
Singh S, Herath K, Nielsen Kahn J, Mann P, Abruzzo G, Motyl M
Bioorg Med Chem Lett
. 2013 Apr;
23(11):3253-6.
PMID: 23623416
Echinocandins and pneumocandins are classes of lipocyclohexapeptides that are broad spectrum antifungal agents. They inhibit fungal specific 1,3-β-glucan synthase activity which is an essential component of the fungal cell wall....
13.
Wang H, Gill C, Lee S, Mann P, Zuck P, Meredith T, et al.
Chem Biol
. 2013 Feb;
20(2):272-84.
PMID: 23438756
Innovative strategies are needed to combat drug resistance associated with methicillin-resistant Staphylococcus aureus (MRSA). Here, we investigate the potential of wall teichoic acid (WTA) biosynthesis inhibitors as combination agents to...
14.
Walker S, Xu Y, Triantafyllou I, Waldman M, Mendrick C, Brown N, et al.
Antimicrob Agents Chemother
. 2011 Aug;
55(11):5099-106.
PMID: 21844320
The echinocandins are a class of semisynthetic natural products that target β-1,3-glucan synthase (GS). Their proven clinical efficacy combined with minimal safety issues has made the echinocandins an important asset...
15.
Macauda M, Erickson P, Miller J, Mann P, Closter L, Krause P
Vector Borne Zoonotic Dis
. 2011 Mar;
11(7):857-62.
PMID: 21417921
Most physicians prescribe Lyme disease antibiotic therapy regimens that are recommended by the Centers for Disease Control and Prevention, the Infectious Disease Society of America, and the National Institutes of...
16.
Cheng C, Shipps Jr G, Yang Z, Sun B, Kawahata N, Soucy K, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6507-14.
PMID: 19875284
The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit...
17.
Branch J, Calero E, Mann P, Jones L, Erwin D, Wright J, et al.
MLO Med Lab Obs
. 2008 Aug;
40(7):30, 32-4, 36.
PMID: 18717499
No abstract available.
18.
Mann P, Goebel E, Barbarich J, Pilione M, Kennett M, Harvill E
Infect Immun
. 2007 Apr;
75(7):3665-72.
PMID: 17452472
While most vaccines consisting of killed bacteria induce high serum antibody titers, they do not always confer protection as effective as that induced by infection, particularly against mucosal pathogens. Bordetella...
19.
Wheat L, Connolly P, Smedema M, Durkin M, Brizendine E, Mann P, et al.
J Antimicrob Chemother
. 2006 Apr;
57(6):1235-9.
PMID: 16627592
Objectives: To determine the activity of newer triazoles against strains of Histoplasma capsulatum resistant to fluconazole. Methods: Susceptibility testing was performed on 17 paired pre- and post-treatment H. capsulatum isolates...