Paul M Dunman
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Explore the profile of Paul M Dunman including associated specialties, affiliations and a list of published articles.
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98
Citations
4338
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Recent Articles
1.
Butman H, Stefaniak M, Walsh D, Gondil V, Young M, Crow A, et al.
Bioorg Med Chem Lett
. 2025 Mar;
121:130164.
PMID: 40043820
Penicillin binding protein 4 (PBP4) is essential for Staphylococcus aureus cortical bone osteocyte lacuno-canalicular network (OLCN) invasion, which causes osteomyelitis and serves as a bacterial niche for recurring bone infection....
2.
Gondil V, Butman H, Young M, Walsh D, Narkhede Y, Zeiler M, et al.
Chem Biol Drug Des
. 2024 Jun;
103(6):e14569.
PMID: 38877369
Staphylococcus aureus has the ability to invade cortical bone osteocyte lacuno-canalicular networks (OLCNs) and cause osteomyelitis. It was recently established that the cell wall transpeptidase, penicillin-binding protein 4 (PBP4), is...
3.
Gowtham L, Wozniak R, Dunman P, Sheba E, Garg P, Joseph J
Cornea
. 2024 Mar;
43(8):1044-1048.
PMID: 38537125
Purpose: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment...
4.
King K, Benton A, Caudill M, Stoyanof S, Kang L, Michalak P, et al.
Mol Microbiol
. 2023 Dec;
121(1):129-141.
PMID: 38082493
Brucella abortus is a facultative, intracellular, zoonotic pathogen that resides inside macrophages during infection. This is a specialized niche where B. abortus encounters various stresses as it navigates through the...
5.
Young M, Chojnacki M, Blanchard C, Cao X, Johnson W, Flaherty D, et al.
Antibiotics (Basel)
. 2023 Jul;
12(7).
PMID: 37508269
is a nosocomial pathogen of serious healthcare concern that is becoming increasingly difficult to treat due to antibiotic treatment failure. Recent studies have revealed that clinically defined antibiotic-susceptible strains upregulate...
6.
Young M, Walsh D, Masters E, Gondil V, Laskey E, Klaczko M, et al.
Antibiotics (Basel)
. 2022 Oct;
11(10).
PMID: 36290009
Methicillin-resistant (MRSA) is a global healthcare concern. Such resistance has historically been attributed to the acquisition of (or ), which encodes an alternative penicillin binding protein, PBP2a, with low β-lactam...
7.
Mei J, Johnson W, Kinn B, Laskey E, Nolin L, Bhamare P, et al.
Transl Vis Sci Technol
. 2022 May;
11(5):26.
PMID: 35612831
Purpose: Pseudomonas aeruginosa is a leading cause of corneal infections. Recently, we discovered an antimicrobial drug combination, polymyxin B/trimethoprim (PT) + rifampin, that displayed impressive efficacy toward P. aeruginosa in...
8.
Johnson W, Sohn M, Taffner S, Chatterjee P, Dunman P, Pecora N, et al.
PLoS One
. 2021 May;
16(5):e0250975.
PMID: 33939761
Staphylococcus aureus is a major cause of ocular infections, often resulting in devastating vision loss. Despite the significant morbidity associated with these infections, little is yet known regarding the specific...
9.
Suigo L, Chojnacki M, Zanotto C, Sebastian-Perez V, De Giuli Morghen C, Casiraghi A, et al.
Antibiotics (Basel)
. 2021 Apr;
10(4).
PMID: 33920000
Antibiotic resistance is spreading worldwide and it has become one of the most important issues in modern medicine. In this context, the bacterial RNA degradation and processing machinery are essential...
10.
Yang H, Kundra S, Chojnacki M, Liu K, Fuse M, Abouelhassan Y, et al.
J Med Chem
. 2021 Apr;
64(11):7275-7295.
PMID: 33881312
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics through the development of resistance and formation of dormant, surface-attached biofilms. Therefore, agents that target and eradicate planktonic and biofilm bacteria...