Paul M C Park
Overview
Explore the profile of Paul M C Park including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
384
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Li Y, Ma M, Hassan M, Hunkeler M, Teng M, Puvar K, et al.
Nat Chem Biol
. 2024 Jul;
20(12):1640-1649.
PMID: 39075252
Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains challenging, requiring innovative mechanistic strategies to stabilize neoprotein interfaces and expedite...
2.
Park P, Park J, Brown J, Hunkeler M, Roy Burman S, Donovan K, et al.
Mol Cell
. 2024 Jul;
84(13):2511-2524.e8.
PMID: 38996460
BCL6, an oncogenic transcription factor (TF), forms polymers in the presence of a small-molecule molecular glue that stabilizes a complementary interface between homodimers of BCL6's broad-complex, tramtrack, and bric-à-brac (BTB)...
3.
Tsai J, Aguirre J, Li Y, Brown J, Focht V, Kater L, et al.
Mol Cell
. 2023 Jul;
83(15):2753-2767.e10.
PMID: 37478846
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation by unknown ligand-dependent ubiquitin ligase machinery. NR degradation is...
4.
Zou C, Yoon H, Park P, Patten J, Pellman J, Carreiro J, et al.
iScience
. 2023 Apr;
26(5):106601.
PMID: 37095859
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the...
5.
Li Y, Ma M, Hassan M, Hunkeler M, Teng M, Puvar K, et al.
bioRxiv
. 2023 Feb;
PMID: 36824856
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics. Molecular glues are of particular interest given their favorable...
6.
Zaiken M, Flynn R, Paz K, Rhee S, Jin S, Mohamed F, et al.
Blood
. 2022 Feb;
139(19):2983-2997.
PMID: 35226736
Despite advances in the field, chronic graft-versus-host-disease (cGVHD) remains a leading cause of morbidity and mortality following allogenic hematopoietic stem cell transplant. Because treatment options remain limited, we tested efficacy...
7.
Durbin A, Wang T, Wimalasena V, Zimmerman M, Li D, Dharia N, et al.
Cancer Discov
. 2021 Nov;
12(3):730-751.
PMID: 34772733
Significance: EP300, but not CBP, controls oncogenic CRC-driven transcription in high-risk NB by binding TFAP2β. We developed JQAD1, a CRBN-dependent PROTAC degrader with preferential activity against EP300 and demonstrated its...
8.
Ohguchi H, Park P, Wang T, Gryder B, Ogiya D, Kurata K, et al.
Blood Cancer Discov
. 2021 Jul;
2(4):370-387.
PMID: 34258103
Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3K4 trimethylation, a histone mark associated with activate gene transcription. We identify that KDM5A interacts with the P-TEFb complex and...
9.
Gryder B, Wu L, Woldemichael G, Pomella S, Quinn T, Park P, et al.
Nat Commun
. 2019 Jul;
10(1):3004.
PMID: 31285436
Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high interest for cancer...
10.
Pak E, MacKenzie E, Zhao X, Pazyra-Murphy M, Park P, Wu L, et al.
Neuro Oncol
. 2019 May;
21(9):1150-1163.
PMID: 31111916
Background: Medulloblastoma (MB) is one of the most frequent malignant brain tumors of children, and a large set of these tumors is characterized by aberrant activation of the sonic hedgehog...