Paul M C Park
Overview
Explore the profile of Paul M C Park including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
384
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0
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Recent Articles
11.
Zhao X, Ren Y, Lawlor M, Shah B, Park P, Lwin T, et al.
Cancer Cell
. 2019 May;
35(5):752-766.e9.
PMID: 31085176
Drug-tolerant "persister" tumor cells underlie emergence of drug-resistant clones and contribute to relapse and disease progression. Here we report that resistance to the BCL-2 targeting drug ABT-199 in models of...
12.
Song Y, Park P, Wu L, Ray A, Picaud S, Li D, et al.
Leukemia
. 2019 Apr;
33(11):2685-2694.
PMID: 30962579
Proteasome inhibition is an effective treatment for multiple myeloma (MM); however, targeting different components of the ubiquitin-proteasome system (UPS) remains elusive. Our RNA-interference studies identified proteasome-associated ubiquitin-receptor Rpn13 as a...
13.
Rivera-Reyes A, Ye S, Marino G, Egolf S, Ciotti G, Chor S, et al.
Cell Death Dis
. 2018 Nov;
9(11):1108.
PMID: 30382078
Terminal differentiation opposes proliferation in the vast majority of tissue types. As a result, loss of lineage differentiation is a hallmark of aggressive cancers, including soft tissue sarcomas (STS). Consistent...
14.
Ye S, Lawlor M, Rivera-Reyes A, Egolf S, Chor S, Pak K, et al.
Cancer Res
. 2018 Mar;
78(10):2705-2720.
PMID: 29490948
To date, no consistent oncogenic driver mutations have been identified in most adult soft tissue sarcomas; these tumors are thus generally insensitive to existing targeted therapies. Here we investigated alternate...
15.
Erwin G, Grieshop M, Ali A, Qi J, Lawlor M, Kumar D, et al.
Science
. 2017 Dec;
358(6370):1617-1622.
PMID: 29192133
The release of paused RNA polymerase II into productive elongation is highly regulated, especially at genes that affect human development and disease. To exert control over this rate-limiting step, we...