Eric S Fischer
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Explore the profile of Eric S Fischer including associated specialties, affiliations and a list of published articles.
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126
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4801
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Recent Articles
1.
Geng Q, Jiang Z, Byun W, Donovan K, Zhuang Z, Jiang F, et al.
J Med Chem
. 2025 Jan;
68(3):3180-3196.
PMID: 39873536
Molecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase, thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind...
2.
Jin C, Hunkeler M, Mulvaney K, Sellers W, Fischer E
J Biol Chem
. 2025 Jan;
301(2):108165.
PMID: 39793893
Protein arginine methyltransferase (PRMT) 5 is an essential arginine methyltransferase responsible for the majority of cellular symmetric dimethyl-arginine marks. PRMT5 uses substrate adaptors such as pICln, RIOK1, and COPR5 to...
3.
Kochen Rossi J, Nuevo-Tapioles C, OKeefe R, Hunkeler M, Schmoker A, Fissore-OLeary M, et al.
Cell Rep
. 2024 Dec;
44(1):115087.
PMID: 39705142
Transcripts of the KRAS locus are alternatively spliced to generate two proteins, KRAS4A and KRAS4B, which differ in their membrane-targeting sequences. These splice variants have been conserved for more than...
4.
Liu S, Hulsman M, Leyendecker P, Chang E, Donovan K, Strobel F, et al.
bioRxiv
. 2024 Dec;
PMID: 39651304
Macrophages engulf apoptotic bodies and cellular debris as part of homeostasis, but they can also phagocytose live cells such as aged red blood cells. Pharmacologic reprogramming with the SMAC mimetic...
5.
Fan A, Gadbois G, Huang H, Chaudhry C, Jiang J, Sigua L, et al.
Angew Chem Int Ed Engl
. 2024 Nov;
64(5):e202417272.
PMID: 39602499
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive...
6.
Razumkov H, Jiang Z, Baek K, You I, Geng Q, Donovan K, et al.
J Am Chem Soc
. 2024 Nov;
146(46):31433-31443.
PMID: 39499896
Small molecules promoting protein-protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like structures and ability to engage targets without reliance...
7.
Zhuang Z, Byun W, Kozicka Z, Dwyer B, Donovan K, Jiang Z, et al.
bioRxiv
. 2024 Oct;
PMID: 39386645
Targeted covalent inhibition (TCI) and targeted protein degradation (TPD) have proven effective in pharmacologically addressing formerly 'undruggable' targets. Integration of both methodologies has resulted in the development of electrophilic degraders...
8.
Fan A, Gadbois G, Huang H, Jiang J, Sigua L, Smith E, et al.
bioRxiv
. 2024 Sep;
PMID: 39345570
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive...
9.
Hassan M, Li Y, Ma M, Teng M, Byun W, Puvar K, et al.
Eur J Med Chem
. 2024 Sep;
279:116904.
PMID: 39341093
Chemically induced proximity modalities such as targeted protein degradation (TPD) hold promise for expanding the number of proteins that can be manipulated pharmacologically. However, current TPD strategies are often limited...
10.
Baek K, Metivier R, Roy Burman S, Bushman J, Yoon H, Lumpkin R, et al.
bioRxiv
. 2024 Sep;
PMID: 39314457
Targeted protein degradation and induced proximity refer to strategies that leverage the recruitment of proteins to facilitate their modification, regulation or degradation. As prospective design of glues remains challenging, unbiased...