Paul J Rozance
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Explore the profile of Paul J Rozance including associated specialties, affiliations and a list of published articles.
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119
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2361
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Recent Articles
1.
Tanner A, Cilvik S, Nguyen M, Dobrinskikh E, Anthony R, Wesolowski S, et al.
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076531
Postnatally, glucagon acutely lowers plasma amino acid (AA) concentrations by stimulating hepatic AA catabolism, but its fetal actions remain unclear. This study tested whether a 2 h fetal glucagon infusion...
2.
White A, Stremming J, Wesolowski S, Al-Juboori S, Dobrinskikh E, Limesand S, et al.
Am J Physiol Endocrinol Metab
. 2024 Dec;
328(1):E116-E125.
PMID: 39679943
Insulin-like growth factor-1 (IGF-1) and insulin are important fetal anabolic hormones. Complications of pregnancy, such as placental insufficiency, can lead to fetal growth restriction (FGR) with low-circulating IGF-1 and insulin...
3.
Gilley S, Ruebel M, Chintapalli S, Wright C, Rozance P, Shankar K
Front Endocrinol (Lausanne)
. 2024 Oct;
15:1423464.
PMID: 39429739
Background: Maternal undernutrition is the most common cause of fetal growth restriction (FGR) worldwide. FGR increases morbidity and mortality during infancy, as well as contributes to adult-onset diseases including obesity...
4.
Cilvik S, Boehmer B, Wesolowski S, Brown L, Rozance P
J Physiol
. 2024 Oct;
602(22):6329-6345.
PMID: 39383208
Fetal glucagon concentrations are elevated in the presence of a compromised intrauterine environment, as in cases of placental insufficiency and perinatal acidaemia. Our objective was to investigate the impact of...
5.
Chang E, Stremming J, Knaub L, Wesolowski S, Rozance P, Sucharov C, et al.
J Physiol
. 2024 May;
602(12):2697-2715.
PMID: 38743350
Fetuses affected by intrauterine growth restriction have an increased risk of developing heart disease and failure in adulthood. Compared with controls, late gestation intrauterine growth-restricted (IUGR) fetal sheep have fewer...
6.
Kennedy V, Lynch C, Tanner A, Winger Q, Gad A, Rozance P, et al.
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731997
Glucose, the primary energy substrate for fetal oxidative processes and growth, is transferred from maternal to fetal circulation down a concentration gradient by placental facilitative glucose transporters. In sheep, SLC2A1...
7.
Stremming J, Chang E, White A, Rozance P, Brown L
J Endocrinol
. 2024 May;
262(1).
PMID: 38727325
Insulin-like growth factor 1 (IGF-1) is a critical fetal anabolic hormone. IGF-1 infusion to the normally growing sheep fetus increases the weight of some organs but does not consistently increase...
8.
Brown L, Rozance P, Wang D, Eroglu E, Wilkening R, Solmonson A, et al.
JCI Insight
. 2024 Apr;
9(10).
PMID: 38687612
Fetal growth restriction (FGR) is accompanied by early activation of hepatic glucose production (HGP), a hallmark of type 2 diabetes (T2D). Here, we used fetal hepatic catheterization to directly measure...
9.
Rozance P, Brown L, Wesolowski S
Reprod Sci
. 2024 Apr;
31(6):1763-1766.
PMID: 38653860
In human pregnancy, metformin administered to the mother crosses the placenta resulting in metformin exposure to the fetus. However, the effects of metformin exposure on the fetus are poorly understood...
10.
Dinu D, Hagan J, Rozance P
Am J Perinatol
. 2024 Apr;
41(14):1990-1998.
PMID: 38565171
Objective: Hypoglycemia, the most common metabolic derangement in the newborn period remains a contentious issue, not only due to various numerical definitions, but also due to limited therapeutical options which...