Paul J Rozance
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Explore the profile of Paul J Rozance including associated specialties, affiliations and a list of published articles.
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119
Citations
2361
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Recent Articles
11.
Tanner A, Kennedy V, Lynch C, Winger Q, Anthony R, Rozance P
Am J Physiol Endocrinol Metab
. 2024 Feb;
326(5):E602-E615.
PMID: 38353640
We previously demonstrated impaired placental nutrient transfer in chorionic somatomammotropin (CSH) RNA interference (RNAi) pregnancies, with glucose transfer being the most impacted. Thus, we hypothesized that despite experimentally elevating maternal...
12.
Gilley S, Zarate M, Zheng L, Jambal P, Yazza D, Chintapalli S, et al.
Pediatr Res
. 2023 Nov;
95(3):647-659.
PMID: 37935884
Background: Fetal growth restriction (FGR) increases risk for development of obesity and type 2 diabetes. Using a mouse model of FGR, we tested whether metabolic outcomes were exacerbated by high-fat...
13.
Hord T, Tanner A, Kennedy V, Lynch C, Winger Q, Rozance P, et al.
Life (Basel)
. 2023 Jun;
13(6).
PMID: 37374044
While fetal growth is dependent on many factors, optimal placental function is a prerequisite for a normal pregnancy outcome. The majority of fetal growth-restricted (FGR) pregnancies result from placental insufficiency...
14.
Swenson K, Wang D, Jones A, Nash M, ORourke R, Takahashi D, et al.
Diabetes
. 2023 Jun;
72(9):1214-1227.
PMID: 37347736
Article Highlights: The major metformin uptake transporter OCT1 is expressed in the fetal liver, and fetal hepatic uptake of metformin is observed in vivo. Metformin activates AMPK, reduces glucose production,...
15.
Kyllo H, Wang D, Lorca R, Julian C, Moore L, Wilkening R, et al.
Am J Physiol Endocrinol Metab
. 2023 May;
324(6):E556-E568.
PMID: 37126847
Glucose, lactate, and amino acids are major fetal nutrients. During placental insufficiency-induced intrauterine growth restriction (PI-IUGR), uteroplacental weight-specific oxygen consumption rates are maintained, yet fetal glucose and amino acid supply...
16.
White A, Stremming J, Brown L, Rozance P
J Dev Orig Health Dis
. 2023 Apr;
14(3):353-361.
PMID: 37114757
Insulin-like growth factor-1 (IGF-1) is a critical fetal growth hormone that has been proposed as a therapy for intrauterine growth restriction. We previously demonstrated that a 1-week IGF-1 LR3 infusion...
17.
Rozance P, Boehmer B, Chang E, Wesolowski S, Brown L
J Nutr
. 2023 Mar;
153(2):493-504.
PMID: 36894241
Background: Leucine increases protein synthesis rates in postnatal animals and adults. Whether supplemental leucine has similar effects in the fetus has not been determined. Objective: To determine the effect of...
18.
Hernandez T, Rozance P
Am J Clin Nutr
. 2023 Feb;
117(2):227-234.
PMID: 36811561
Evidence-based dietary reference intakes for nutrients in healthy individuals were last set in 2005 by the Institute of Medicine. For the first time, these recommendations included a guideline for carbohydrate...
19.
Lynch C, Kennedy V, Tanner A, Ali A, Winger Q, Rozance P, et al.
Int J Mol Sci
. 2022 Oct;
23(20).
PMID: 36293384
In the ruminant placenta, glucose uptake and transfer are mediated by facilitative glucose transporters SLC2A1 (GLUT1) and SLC2A3 (GLUT3). SLC2A1 is located on the basolateral trophoblast membrane, whereas SLC2A3 is...
20.
Stenhouse C, Halloran K, Tanner A, Suva L, Rozance P, Anthony R, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35887141
Minerals are required for the establishment and maintenance of pregnancy and regulation of fetal growth in mammals. Lentiviral-mediated RNA interference (RNAi) of chorionic somatomammotropin hormone (CSH) results in both an...