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Paul Hoover

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Articles 24
Citations 3270
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Recent Articles
1.
McSweeney K, Hoover P, Ramirez-Solano M, Liu Q, Schwartz J
Exp Hematol . 2024 Jun; 137:104249. PMID: 38848876
Inherited bone marrow failure syndromes often result from pathogenic mutations in genes that are important for ribosome function, namely, Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita. Germline mutations in SAMD9...
2.
Gipson D, Wang C, Salmon E, Gbadegesin R, Naik A, Sanna-Cherchi S, et al.
Glomerular Dis . 2024 Feb; 4(1):1-10. PMID: 38348154
No abstract available.
3.
Fava A, Buyon J, Magder L, Hodgin J, Rosenberg A, Demeke D, et al.
JCI Insight . 2024 Jan; 9(2. PMID: 38258904
Lupus nephritis (LN) is a pathologically heterogenous autoimmune disease linked to end-stage kidney disease and mortality. Better therapeutic strategies are needed as only 30%-40% of patients completely respond to treatment....
4.
Todorovic V, McDonald H, Hoover P, Wetter J, Marinopoulos A, Woody C, et al.
Exp Dermatol . 2022 Feb; 31(7):1036-1047. PMID: 35213752
Psoriasis vulgaris is an inflammatory skin disease that affects 2%-3% of the population worldwide. One of the major challenges in discovering novel therapies is the poor translatability of animal models...
5.
Minasov G, Rosas-Lemus M, Shuvalova L, Inniss N, Brunzelle J, Daczkowski C, et al.
Sci Signal . 2021 Jun; 14(689). PMID: 34131072
Capping of viral messenger RNAs is essential for efficient translation, for virus replication, and for preventing detection by the host cell innate response system. The SARS-CoV-2 genome encodes the 2'--methyltransferase...
6.
Kaminski P, Hong S, Kono T, Hoover P, Laimins L
mBio . 2021 Feb; 12(1). PMID: 33563836
Topoisomerases regulate higher-order chromatin structures through the transient breaking and religating of one or both strands of the phosphodiester backbone of duplex DNA. TOP2β is a type II topoisomerase that...
7.
El-Achkar T, Eadon M, Menon R, Lake B, Sigdel T, Alexandrov T, et al.
Physiol Genomics . 2020 Nov; 53(1):1-11. PMID: 33197228
Comprehensive and spatially mapped molecular atlases of organs at a cellular level are a critical resource to gain insights into pathogenic mechanisms and personalized therapies for diseases. The Kidney Precision...
8.
Kono T, Hoover P, Poropatich K, Paunesku T, Mittal B, Samant S, et al.
Virology . 2020 Jun; 547:27-34. PMID: 32560902
The mechanisms regulating viral pathogenesis of human papillomavirus (HPV) associated oropharyngeal squamous cell cancers (OPSCC) are not well understood. In the cervix, activation of DNA damage repair pathways is critical...
9.
Menon R, Otto E, Hoover P, Eddy S, Mariani L, Godfrey B, et al.
JCI Insight . 2020 Feb; 5(6). PMID: 32107344
To define cellular mechanisms underlying kidney function and failure, the KPMP analyzes biopsy tissue in a multicenter research network to build cell-level process maps of the kidney. This study aimed...
10.
Li B, Clohisey S, Chia B, Wang B, Cui A, Eisenhaure T, et al.
Nat Commun . 2020 Jan; 11(1):164. PMID: 31919360
Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous...