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Paul E Gray

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Recent Articles
11.
Tajbakhsh Z, Jalbert I, Stapleton F, Alghamdi A, Gray P, Briggs N, et al.
Eye (Lond) . 2023 Feb; 37(13):2768-2775. PMID: 36747108
Background: Increased density and altered morphology of dendritic cells (DC) in the cornea and conjunctiva occur during active allergic conjunctivitis. This study investigated whether inflammation (characterised by altered DC density...
12.
Noori T, Rudd-Schmidt J, Kane A, Frith K, Gray P, Hu H, et al.
Blood . 2023 Jan; 141(19):2330-2342. PMID: 36706356
Familial forms of the severe immunoregulatory disease hemophagocytic lymphohistiocytosis (HLH) arise from biallelic mutations in the PRF1, UNC13D, STXBP2, and STX11 genes. Early and accurate diagnosis of the disease is...
13.
Sokal A, Bastard P, Chappert P, Barba-Spaeth G, Fourati S, Vanderberghe A, et al.
J Exp Med . 2022 Nov; 220(1). PMID: 36342455
Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with...
14.
Yang R, Avery D, Jackson K, Ogishi M, Benhsaien I, Du L, et al.
Sci Immunol . 2022 Jul; 7(73):eabq3277. PMID: 35867801
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct murine B cell population known as "age-associated B cells" (ABCs). T-bet-deficient mice have reduced ABCs and impaired humoral immunity....
15.
Huynh A, Siggs O, Wainstein B, Gray P
Ocul Immunol Inflamm . 2022 May; 31(5):1097-1100. PMID: 35622932
Background: Orbital myositis is a rare sporadic eye disease associated with extraocular eye muscle inflammation. To date, there have been two reports of familial orbital myositis (FOM), which demonstrate partially...
16.
Gray P, Bartlett A, Tangye S
Clin Transl Immunology . 2022 Apr; 11(4):e1365. PMID: 35444807
Since the emergence of the COVID-19 pandemic in early 2020, a key challenge has been to define risk factors, other than age and pre-existing comorbidities, that predispose some people to...
17.
Howard-Jones A, Burgner D, Crawford N, Goeman E, Gray P, Hsu P, et al.
J Paediatr Child Health . 2021 Oct; 58(1):46-53. PMID: 34694037
The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of...
18.
Yap J, Moens L, Lin M, Kane A, Kelleher A, Toong C, et al.
J Clin Immunol . 2021 Oct; 41(8):1915-1935. PMID: 34657246
Purpose: Deficiency of adenosine deaminase type 2 (ADA2) (DADA2) is a rare inborn error of immunity caused by deleterious biallelic mutations in ADA2. Clinical manifestations are diverse, ranging from severe...
19.
Tangye S, Gray P, Pillay B, Yap J, Figgett W, Reeves J, et al.
J Clin Immunol . 2021 Oct; 42(1):119-129. PMID: 34657245
Rare, biallelic loss-of-function mutations in DOCK8 result in a combined immune deficiency characterized by severe and recurrent cutaneous infections, eczema, allergies, and susceptibility to malignancy, as well as impaired humoral...
20.
Howard-Jones A, Bowen A, Danchin M, Koirala A, Sharma K, Yeoh D, et al.
J Paediatr Child Health . 2021 Oct; 58(1):39-45. PMID: 34643307
Children globally have been profoundly impacted by the coronavirus disease 2019 (COVID-19) pandemic. This review explores the direct and indirect public health impacts of COVID-19 on children. We discuss in...