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Paul E Gray

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Articles 35
Citations 481
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Recent Articles
1.
Rao G, Mack C, Nguyen T, Wong N, Payne K, Worley L, et al.
J Allergy Clin Immunol . 2024 Dec; PMID: 39622295
Background: CD4 T cells play essential roles in adaptive immunity. Distinct CD4 T-cell subsets-T1, T2, T17, T22, T follicular helper, and regulatory T cells-have been identified, and their contributions to...
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Ogishi M, Kitaoka K, Good-Jacobson K, Rinchai D, Zhang B, Wang J, et al.
Immunity . 2024 Nov; 57(12):2790-2807.e15. PMID: 39603236
T follicular helper (Tfh) cells abundantly express the immunoreceptor programmed cell death protein 1 (PD-1), and the impact of PD-1 deficiency on antibody (Ab)-mediated immunity in mice is associated with...
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Huynh A, Gray P, Sullivan A, Mackie J, Guerin A, Rao G, et al.
J Clin Immunol . 2024 Aug; 44(8):170. PMID: 39098944
Advanced genomic technologies such as whole exome or whole genome sequencing have improved diagnoses and disease outcomes for individuals with genetic diseases. Yet, variants of unknown significance (VUS) require rigorous...
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Davidson S, Shibata Y, Collard S, Zheng H, Kong K, Sun J, et al.
J Exp Med . 2024 Apr; 221(6). PMID: 38630025
OTU deubiquitinase with linear linkage specificity (OTULIN) regulates inflammation and cell death by deubiquitinating linear ubiquitin chains generated by the linear ubiquitin chain assembly complex (LUBAC). Biallelic loss-of-function mutations causes...
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Li M, Burnett L, Dai P, Avery D, Noori T, Voskoboinik I, et al.
J Clin Immunol . 2024 Jan; 44(1):38. PMID: 38165470
Background: X-linked reticular pigmentary disorder (XLPDR) is a rare condition characterized by skin hyperpigmentation, ectodermal features, multiorgan inflammation, and recurrent infections. All probands identified to date share the same intronic...
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Le Voyer T, Parent A, Liu X, Cederholm A, Gervais A, Rosain J, et al.
Nature . 2023 Nov; 623(7988):803-813. PMID: 37938781
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs), conferring a predisposition to life-threatening COVID-19 pneumonia. Here...
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Reygaerts T, Laohamonthonkul P, Hrovat-Schaale K, Moghaddas F, Baker P, Gray P, et al.
Rheumatology (Oxford) . 2023 Jul; 63(3):882-890. PMID: 37481715
Objective: The p.E148Q variant in pyrin is present in different populations at a frequency of up to 29%, and has been associated with diseases, including vasculitis and FMF. The pathogenicity...
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Tajbakhsh Z, Golebiowski B, Stapleton F, Alghamdi A, Gray P, Altavilla B, et al.
Eye (Lond) . 2023 Feb; 37(14):2896-2904. PMID: 36747109
Background: Corneal and conjunctival epithelial dendritic cells (DC) have an established role in vernal keratoconjunctivitis, however, their role in more prevalent forms of allergic eye disease remains unclear. This study...