Paul D Kassner
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Explore the profile of Paul D Kassner including associated specialties, affiliations and a list of published articles.
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18
Citations
393
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Recent Articles
11.
Rex K, Jeffries S, Brown M, Carlson T, Coxon A, Fajardo F, et al.
PLoS One
. 2013 Jul;
8(7):e68328.
PMID: 23861887
Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the well established role of extracellular S1P as a mitogen...
12.
Nolan-Stevaux O, Tedesco D, Ragan S, Makhanov M, Chenchik A, Ruefli-Brasse A, et al.
PLoS One
. 2013 Jul;
8(6):e67316.
PMID: 23840661
Advances in the fields of cancer initiating cells and high-throughput in vivo shRNA screens have highlighted a need to observe the growth of tumor cells in cancer models at the...
13.
Babij C, Zhang Y, Kurzeja R, Munzli A, Shehabeldin A, Fernando M, et al.
Cancer Res
. 2011 Jul;
71(17):5818-26.
PMID: 21742770
Despite the prevalence of KRAS mutations in human cancers, there remain no targeted therapies for treatment. The serine-threonine kinase STK33 has been proposed to be required for the survival of...
14.
Swearingen E, Fajardo F, Wang X, Watson J, Quon K, Kassner P
J Biomol Screen
. 2010 Apr;
15(5):469-77.
PMID: 20371867
Screening small interfering RNA (siRNA) libraries holds the potential to elucidate gene function as well as discover new targets for the therapeutic treatment of disease. Since the inception of siRNA...
15.
Quon K, Kassner P
Expert Opin Ther Targets
. 2009 Aug;
13(9):1027-35.
PMID: 19650760
RNA interference (RNAi) mediated loss-of-function screens have the potential to delineate biological functions of genes and the proteins they encode. RNAi has proven to be a promising technology for identification...
16.
Kassner P
Comb Chem High Throughput Screen
. 2008 Mar;
11(3):175-84.
PMID: 18336211
High throughput technologies have the potential to affect all aspects of drug discovery. Considerable attention is paid to high throughput screening (HTS) for small molecule lead compounds. The identification of...
17.
Cutler G, Marshall L, Chin N, Baribault H, Kassner P
Genome Res
. 2007 Nov;
17(12):1743-54.
PMID: 17989247
The contribution to genetic diversity of genomic segmental copy number variations (CNVs) is less well understood than that of single-nucleotide polymorphisms (SNPs). While less frequent than SNPs, CNVs have greater...
18.