Paul C Trippier
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Explore the profile of Paul C Trippier including associated specialties, affiliations and a list of published articles.
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58
Citations
636
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Recent Articles
1.
Dow L, Pathirage R, Erickson H, Amani E, Ronning D, Trippier P
RSC Med Chem
. 2024 Dec;
PMID: 39618963
Alzheimer's disease (AD) is estimated to affect over 55 million people across the world. Small molecule treatment options are limited to symptom management with no impact on disease progression. The...
2.
Daria S, Kumar D, Gautam N, Alamoudi J, Dow L, Trippier P, et al.
Xenobiotica
. 2024 Sep;
54(9):711-722.
PMID: 39282717
LD14b is an amyloid-β (Aβ) 17β-hydroxysteroid dehydrogenase type 10 (Aβ-17β-HSD10) protein-protein interaction modulator that shows promising and activity to rescue Aβ-induced mitochondrial dysfunction, Aβ-induced toxicity, and Aβ-mediated inhibition of estradiol...
3.
Jonnalagadda S, Duan L, Dow L, Boligala G, Kosmacek E, McCoy K, et al.
ChemMedChem
. 2024 Jul;
19(21):e202400081.
PMID: 38976686
A series of 7-substituted coumarin derivatives have been characterized as pan-aldo-keto reductase family 1C (AKR1C) inhibitors. The AKR1C family of enzymes are overexpressed in numerous cancers where they are involved...
4.
Carmona A, Jonnalagadda S, Case A, Maddeboina K, Jonnalagadda S, Dow L, et al.
Commun Chem
. 2024 Apr;
7(1):95.
PMID: 38684887
Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7)...
5.
Rahman M, Esfahani S, Zhang Y, Queen A, Aljarrah M, Kandil H, et al.
ACS Med Chem Lett
. 2024 Apr;
15(4):510-517.
PMID: 38628788
The peptidase neurolysin (Nln) has been validated as a potential target for developing therapeutics for ischemic stroke (IS). Overexpression of Nln in a mouse model of IS provides significant cerebroprotection,...
6.
Dow L, Case A, Paustian M, Pinkerton B, Simeon P, Trippier P
RSC Med Chem
. 2023 Nov;
14(11):2206-2230.
PMID: 37974956
There is a myriad of enzymes within the body responsible for maintaining homeostasis by providing the means to convert substrates to products as and when required. Physiological enzymes are tightly...
7.
Zhang Y, Sharma S, Jonnalagadda S, Kumari S, Queen A, Esfahani S, et al.
Pharm Res
. 2023 Oct;
40(11):2747-2758.
PMID: 37833570
Purpose: There is growing interest in seeking pharmacological activation of neurolysin (Nln) for stroke treatment. Discovery of central nervous system drugs remains challenging due to the protection of the blood-brain...
8.
Maddeboina K, Jonnalagadda S, Morsy A, Duan L, Chhonker Y, Murry D, et al.
J Med Chem
. 2023 Jul;
66(14):9894-9915.
PMID: 37428858
Aldo-keto reductase 1C3 (AKR1C3) is overexpressed in castration-resistant prostate cancer where it acts to drive proliferation and aggressiveness by producing androgens. The reductive action of the enzyme leads to chemoresistance...
9.
Blanco M, Bryant-Friedrich A, Georg G, Ali A, Ornstein P, Ferrins L, et al.
ACS Med Chem Lett
. 2023 Jun;
14(6):682-684.
PMID: 37312854
The American Chemical Society Division of Medicinal Chemistry (MEDI) confers a range of awards, fellowships and honors to recognize excellence in medicinal chemistry. To celebrate the creation of the Gertrude...
10.
Shahbazi Nia S, Hossain M, Ji G, Jonnalagadda S, Obeng S, Rahman M, et al.
Eur J Med Chem
. 2023 Apr;
254:115309.
PMID: 37054561
Using the structure of gliotoxin as a starting point, we have prepared two different chemotypes with selective affinity to the kappa opioid receptor (KOR). Using medicinal chemistry approaches and structure-activity...