Paul Bertone
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Explore the profile of Paul Bertone including associated specialties, affiliations and a list of published articles.
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Articles
71
Citations
7172
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Recent Articles
1.
Jimenez-Macias J, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, et al.
Sci Adv
. 2025 Feb;
11(9):eadr1481.
PMID: 40009687
Efficient drug delivery to glioblastoma (GBM) is a major obstacle as the blood-brain barrier (BBB) and the blood-tumor barrier (BTB) prevent passage of the majority of chemotherapies into the brain....
2.
Singh N, Eickhoff C, Garcia-Agundez A, Bertone P, Paudel S, Tambe D, et al.
Sci Rep
. 2023 Dec;
13(1):22534.
PMID: 38110438
Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can...
3.
Petersen M, Chorzalska A, Pardo M, Rodriguez A, Morgan J, Ahsan N, et al.
Mol Oncol
. 2023 Jan;
17(11):2356-2379.
PMID: 36635880
Dysregulation of the adaptor protein Abelson interactor 1 (ABI1) is linked to malignant transformation. To interrogate the role of ABI1 in cancer development, we mapped the ABI1 interactome using proximity-dependent...
4.
Labouesse C, Tan B, Agley C, Hofer M, Winkel A, Stirparo G, et al.
Nat Commun
. 2021 Oct;
12(1):6132.
PMID: 34675200
Studies of mechanical signalling are typically performed by comparing cells cultured on soft and stiff hydrogel-based substrates. However, it is challenging to independently and robustly control both substrate stiffness and...
5.
Soliman L, De Souza A, Srinivasan P, Danish M, Bertone P, El-Deiry W, et al.
Am J Clin Oncol
. 2021 May;
44(7):374-382.
PMID: 34014842
The development of androgen resistance in advanced prostate cancer remains a challenging clinical problem. Because androgen deprivation therapy constitutes the backbone of first-line treatments for metastatic prostate cancer, the phenotypic...
6.
Gangoso E, Southgate B, Bradley L, Rus S, Galvez-Cancino F, McGivern N, et al.
Cell
. 2021 Apr;
184(9):2454-2470.e26.
PMID: 33857425
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms underlying immune evasion in GBM. By serially transplanting GBM...
7.
Tremble K, Stirparo G, Bates L, Maskalenka K, Stuart H, Jones K, et al.
iScience
. 2021 Mar;
24(3):102153.
PMID: 33665571
Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression...
8.
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al.
Cell Stem Cell
. 2019 Aug;
25(3):388-406.e8.
PMID: 31422912
Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of...
9.
Pekowska A, Klaus B, Xiang W, Severino J, Daigle N, Klein F, et al.
Cell Syst
. 2018 Nov;
7(5):482-495.e10.
PMID: 30414923
The genome of pluripotent stem cells adopts a unique three-dimensional architecture featuring weakly condensed heterochromatin and large nucleosome-free regions. Yet, it is unknown whether structural loops and contact domains display...
10.
Boroviak T, Stirparo G, Dietmann S, Hernando-Herraez I, Mohammed H, Reik W, et al.
Development
. 2018 Nov;
145(21).
PMID: 30413530
The mouse embryo is the canonical model for mammalian preimplantation development. Recent advances in single cell profiling allow detailed analysis of embryogenesis in other eutherian species, including human, to distinguish...