Jennifer Nichols
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Explore the profile of Jennifer Nichols including associated specialties, affiliations and a list of published articles.
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Articles
138
Citations
14214
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Recent Articles
1.
Ying Q, Nichols J
Bioessays
. 2024 Oct;
46(12):e2400077.
PMID: 39400400
Pluripotent stem cell lines derived from preimplantation mouse embryos have opened opportunities for the study of early mammalian development and generation of genetically uncompromised material for differentiation into specific cell...
2.
Simpson L, Strange A, Klisch D, Kraunsoe S, Azami T, Goszczynski D, et al.
Nat Commun
. 2024 Jun;
15(1):5210.
PMID: 38890321
Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we...
3.
Corujo-Simon E, Bates L, Yanagida A, Jones K, Clark S, von Meyenn F, et al.
Dev Cell
. 2024 Jun;
59(18):2497-2505.e4.
PMID: 38889726
To implant in the uterus, mammalian embryos form blastocysts comprising trophectoderm (TE) surrounding an inner cell mass (ICM), confined to the polar region by the expanding blastocoel. The mode of...
4.
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification
Dattani A, Corujo-Simon E, Radley A, Heydari T, Taheriabkenar Y, Carlisle F, et al.
Cell Stem Cell
. 2024 Jun;
31(7):1058-1071.e5.
PMID: 38823388
The hypoblast is an essential extraembryonic tissue set aside within the inner cell mass in the blastocyst. Research with human embryos is challenging. Thus, stem cell models that reproduce hypoblast...
5.
6.
Imaz-Rosshandler I, Rode C, Guibentif C, Harland L, Ton M, Dhapola P, et al.
Development
. 2023 Nov;
151(3).
PMID: 37982461
Early organogenesis represents a key step in animal development, during which pluripotent cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell transcriptomes from mouse embryos between E8.5 and...
7.
Turner D, Nichols J
Curr Opin Genet Dev
. 2023 Oct;
83:102130.
PMID: 37897953
How functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understanding developmental defects and diseases. Dissecting developmental processes provides the basic, critical...
8.
Strawbridge S, Kurowski A, Corujo-Simon E, Fletcher A, Nichols J, Fletcher A
Biol Open
. 2023 Aug;
12(9).
PMID: 37623821
A crucial aspect of embryology is relating the position of individual cells to the broader geometry of the embryo. A classic example of this is the first cell-fate decision of...
9.
Farley A, Chengrui A, Palmer S, Liu D, Kousa A, Rouse P, et al.
Front Immunol
. 2023 Aug;
14:1202163.
PMID: 37559721
During development, cortical (c) and medullary (m) thymic epithelial cells (TEC) arise from the third pharyngeal pouch endoderm. Current models suggest that within the thymic primordium most TEC exist in...
10.
Cooke C, Barrington C, Baillie-Benson P, Nichols J, Moris N
Development
. 2023 Aug;
150(17).
PMID: 37526602
Primordial germ cells (PGCs) are the early embryonic precursors of gametes - sperm and egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells exposed to...