Paul A Lindahl
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Explore the profile of Paul A Lindahl including associated specialties, affiliations and a list of published articles.
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98
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1409
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Recent Articles
1.
Delanoy G, Lupardus C, Vali S, Wofford J, Thorat S, Lindahl P
J Biol Chem
. 2024 Aug;
300(9):107711.
PMID: 39178945
The kinetics of iron trafficking in whole respiring Saccharomyces cerevisiae cells were investigated using Mössbauer and EPR spectroscopies. The Mössbauer-active isotope Fe was added to cells growing under iron-limited conditions;...
2.
Lindahl P
Methods Mol Biol
. 2024 Jul;
2839:3-29.
PMID: 39008245
Over the past 30 years, much has been learned regarding iron homeostatic regulation in budding yeast, S. cerevisiae, including the identity of many of the proteins and molecular-level regulatory mechanisms...
3.
Walton J, Lindahl P
iScience
. 2024 Jan;
27(1):108506.
PMID: 38161422
This contribution treats linear, steady-state dynamics for a metabolic network within a growing cell. Admissible steady-state reaction fluxes are assumed to form a pointed, convex, polyhedral, conical subset of the...
4.
Thorat S, Walton J, Lindahl P
PLoS Comput Biol
. 2023 Dec;
19(12):e1011701.
PMID: 38113197
Iron is an essential transition metal for all eukaryotic cells, and its trafficking throughout the cell is highly regulated. However, the overall cellular mechanism of regulation is poorly understood despite...
5.
Kim J, Jeon S, Lindahl P
J Biol Chem
. 2023 Nov;
299(12):105435.
PMID: 37944620
Copper is essential for all eukaryotic cells but many details of how it is trafficked within the cell and how it is homeostatically regulated remain uncertain. Here, we characterized the...
6.
Shepherd R, Kreinbrink A, Njimoh C, Vali S, Lindahl P
J Am Chem Soc
. 2023 Jun;
145(25):13556-13569.
PMID: 37339084
Iron-sulfur cluster (ISC) assembly occurs in both mitochondria and cytosol. Mitochondria are thought to export a low-molecular-mass (LMM) iron and/or sulfur species which is used as a substrate for cytosolic...
7.
Brawley H, Kreinbrink A, Hierholzer J, Vali S, Lindahl P
J Am Chem Soc
. 2023 Jan;
145(4):2104-2117.
PMID: 36661842
The existence of labile iron pools (LFePs) in biological systems has been recognized for decades, but their chemical composition remains uncertain. Here, the LFeP in cytosol from was investigated. Mössbauer...
8.
Vali S, Lindahl P
J Biol Inorg Chem
. 2022 Dec;
28(2):173-185.
PMID: 36512071
Hereditary hemochromatosis is an iron-overload disease most often arising from a mutation in the Homeostatic Fe regulator (HFE) gene. HFE organs become overloaded with iron which causes damage. Iron-overload is...
9.
Kim J, Lindahl P
Biochemistry
. 2022 Dec;
62(1):62-74.
PMID: 36503220
Liquid chromatography, mass spectrometry, and metal analyses of cytosol and mitochondrial filtrates from healthy copper-replete cells revealed that metallothionein CUP1 was a notable copper-containing species in both compartments, with its...
10.
Vali S, Lindahl P
J Biol Chem
. 2022 Nov;
298(12):102667.
PMID: 36334631
The HFE (Homeostatic Fe regulator) gene is commonly mutated in hereditary hemochromatosis. Blood of (HFE)(-/-) mice and of humans with hemochromatosis contains toxic nontransferrin-bound iron (NTBI) which accumulates in organs....