Paul A Hargrave
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Explore the profile of Paul A Hargrave including associated specialties, affiliations and a list of published articles.
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11
Citations
273
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Recent Articles
1.
Deretic D, Williams A, Ransom N, Morel V, Hargrave P, Arendt A
Proc Natl Acad Sci U S A
. 2005 Feb;
102(9):3301-6.
PMID: 15728366
The maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the human disease autosomal dominant retinitis pigmentosa. The severe form mutations occur in the C-terminal sorting signal...
2.
Edwards P, Li J, Burghammer M, McDowell J, Villa C, Hargrave P, et al.
J Mol Biol
. 2004 Oct;
343(5):1439-50.
PMID: 15491622
Rhodopsin, the pigment protein responsible for dim-light vision, is a G protein-coupled receptor that converts light absorption into the activation of a G protein, transducin, to initiate the visual response....
3.
Kisselev O, Downs M, McDowell J, Hargrave P
J Biol Chem
. 2004 Sep;
279(49):51203-7.
PMID: 15351781
Phosphorylation of activated G-protein-coupled receptors and the subsequent binding of arrestin mark major molecular events of homologous desensitization. In the visual system, interactions between arrestin and the phosphorylated rhodopsin are...
4.
Kisselev O, McDowell J, Hargrave P
FEBS Lett
. 2004 Apr;
564(3):307-11.
PMID: 15111114
Visual arrestin binds to the phosphorylated carboxy-terminal region of rhodopsin to block interactions with transducin and terminate signaling in the rod photoreceptor cells. A synthetic seven-phospho-peptide from the C-terminal region...
5.
Bailey B, Mumey B, Hargrave P, Arendt A, Ernst O, Hofmann K, et al.
Protein Sci
. 2003 Oct;
12(11):2453-75.
PMID: 14573859
Rhodopsin is the best-understood member of the large G protein-coupled receptor (GPCR) superfamily. The G-protein amplification cascade is triggered by poorly understood light-induced conformational changes in rhodopsin that are homologous...
6.
Pennesi G, Mattapallil M, Sun S, Avichezer D, Silver P, Karabekian Z, et al.
J Clin Invest
. 2003 Apr;
111(8):1171-80.
PMID: 12697736
Experimental autoimmune uveitis (EAU) is a disease of the neural retina induced by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein (IRBP) and arrestin (retinal soluble antigen, S-Ag). EAU...
7.
Peterson J, Tam B, Moritz O, Shelamer C, Dugger D, McDowell J, et al.
Exp Eye Res
. 2003 Apr;
76(5):553-63.
PMID: 12697419
Subcellular translocation of phototransduction proteins in response to light has previously been detected by immunocytochemistry. This movement is consistent with the hypothesis that migration is part of a basic cellular...
8.
Jiang S, Arendt A, Hargrave P, Adamus G
Cell Immunol
. 2002 Nov;
217(1-2):87-94.
PMID: 12426004
Lewis rats immunized with myelin basic protein (MBP) developed experimental autoimmune encephalomyelitis (EAE) and associated anterior uveitis (AU). Although several cryptic epitopes of MBP have strong encephalitogenic and uveitogenic properties,...
9.
Shilton B, McDowell J, Smith W, Hargrave P
Eur J Biochem
. 2002 Aug;
269(15):3801-9.
PMID: 12153577
Visual arrestin is converted from a 'basal' state to an 'activated' state by interaction with the phosphorylated C-terminus of photoactivated rhodopsin (R*), but the conformational changes in arrestin that lead...
10.