Patrik Engstrom
Overview
Explore the profile of Patrik Engstrom including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
269
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0
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Recent Articles
1.
Tongluan N, Engstrom P, Jirakanwisal K, Langohr I, Welch M, Macaluso K
Infect Immun
. 2024 Jan;
92(2):e0051523.
PMID: 38206007
is a pathogen of public health concern and transmitted by the Gulf Coast tick, . Rickettsiae are obligate intracellular bacteria that enter and replicate in diverse host cells. Rickettsial outer...
2.
Borgo G, Burke T, Tran C, Lo N, Engstrom P, Welch M
Nat Commun
. 2022 Jun;
13(1):3656.
PMID: 35760786
Rickettsia species of the spotted fever group are arthropod-borne obligate intracellular bacteria that can cause mild to severe human disease. These bacteria invade host cells, replicate in the cell cytosol,...
3.
Burke T, Engstrom P, Tran C, Langohr I, Glasner D, Espinosa D, et al.
Elife
. 2021 Aug;
10.
PMID: 34423779
Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infection....
4.
Engstrom P, Burke T, Tran C, Iavarone A, Welch M
Sci Adv
. 2021 Jun;
7(26).
PMID: 34172444
Many intracellular pathogens avoid detection by their host cells. However, it remains unknown how they avoid being tagged by ubiquitin, an initial step leading to antimicrobial autophagy. Here, we show...
5.
Bastounis E, Serrano-Alcalde F, Radhakrishnan P, Engstrom P, Gomez-Benito M, Oswald M, et al.
Dev Cell
. 2021 Feb;
56(4):443-460.e11.
PMID: 33621492
Intracellular pathogens alter their host cells' mechanics to promote dissemination through tissues. Conversely, host cells may respond to the presence of pathogens by altering their mechanics to limit infection. Here,...
6.
Burke T, Engstrom P, Chavez R, Fonbuena J, Vance R, Welch M
Nat Microbiol
. 2020 Mar;
5(5):688-696.
PMID: 32123346
The innate immune system fights infection with inflammasomes and interferons. Facultative bacterial pathogens that inhabit the host cytosol avoid inflammasomes and are often insensitive to type I interferons (IFN-I), but...
7.
Engstrom P, Burke T, Mitchell G, Ingabire N, Mark K, Golovkine G, et al.
Nat Microbiol
. 2019 Oct;
4(12):2538-2551.
PMID: 31611642
Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step...
8.
Cheng M, Chen C, Engstrom P, Portnoy D, Mitchell G
Cell Microbiol
. 2018 May;
20(9):e12854.
PMID: 29726107
Listeria monocytogenes grows in the host cytosol and uses the surface protein ActA to promote actin polymerisation and mediate actin-based motility. ActA, along with two secreted bacterial phospholipases C, also...
9.
Mojica S, Salin O, Bastidas R, Sunduru N, Hedenstrom M, Andersson C, et al.
Antimicrob Agents Chemother
. 2017 Aug;
61(10).
PMID: 28784680
The type II fatty acid synthesis (FASII) pathway is essential for bacterial lipid biosynthesis and continues to be a promising target for novel antibacterial compounds. Recently, it has been demonstrated...
10.
Good J, Silver J, Nunez-Otero C, Bahnan W, Krishnan K, Salin O, et al.
J Med Chem
. 2016 Feb;
59(5):2094-108.
PMID: 26849778
The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We recently identified a compound through phenotypic screening that blocked infectivity...