K Syam Krishnan
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Explore the profile of K Syam Krishnan including associated specialties, affiliations and a list of published articles.
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11
Citations
138
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Recent Articles
1.
Flentie K, Harrison G, Tukenmez H, Livny J, Good J, Sarkar S, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(21):10510-10517.
PMID: 31061116
() killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses imposed by the immune system and tolerate exposure to antibiotics,...
2.
Good J, Kulen M, Silver J, Krishnan K, Bahnan W, Nunez-Otero C, et al.
J Med Chem
. 2017 Oct;
60(22):9393-9399.
PMID: 29053275
Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection trachoma. We recently discovered 3-amido...
3.
Preethalayam P, Krishnan K, Thulasi S, Chand S, Joseph J, Nair V, et al.
Chem Rev
. 2017 Feb;
117(5):3930-3989.
PMID: 28151643
Pentafulvenes are a unique class of compounds that originally attracted attention due to their propensity to display nonbenzenoid aromaticity. Subsequently, they were recognized as valuable synthons for the construction of...
4.
Shaffer C, Good J, Kumar S, Krishnan K, Gaddy J, Loh J, et al.
mBio
. 2016 Apr;
7(2):e00221-16.
PMID: 27118587
Unlabelled: Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into target cells. Despite the importance of T4SSs in bacterial pathogenesis, the mechanism by...
5.
Good J, Andersson C, Hansen S, Wall J, Krishnan K, Begum A, et al.
Cell Chem Biol
. 2016 Mar;
23(3):404-14.
PMID: 26991105
The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human bacterial pathogen Listeria monocytogenes. Phenotypic screening...
6.
Good J, Silver J, Nunez-Otero C, Bahnan W, Krishnan K, Salin O, et al.
J Med Chem
. 2016 Feb;
59(5):2094-108.
PMID: 26849778
The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We recently identified a compound through phenotypic screening that blocked infectivity...
7.
Singh P, Chorell E, Krishnan K, Kindahl T, Aden J, Wittung-Stafshede P, et al.
Org Lett
. 2015 Dec;
17(24):6194-7.
PMID: 26650849
An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C-H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their...
8.
Engstrom P, Bergstrom M, Alfaro A, Krishnan K, Bahnan W, Almqvist F, et al.
Int J Med Microbiol
. 2015 Mar;
305(3):378-82.
PMID: 25771502
Chlamydia trachomatis replication takes place inside of a host cell, exclusively within a vacuole known as the inclusion. During an infection, the inclusion expands to accommodate the increasing numbers of...
9.
Engstrom P, Krishnan K, Ngyuen B, Chorell E, Normark J, Silver J, et al.
mBio
. 2015 Jan;
6(1):e02304-14.
PMID: 25550323
Unlabelled: In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A fluorescent KSK120 analogue was synthesized and observed...
10.
Krishnan K, Bengtsson C, Good J, Mirkhanov S, Chorell E, Johansson L, et al.
J Org Chem
. 2013 Oct;
78(23):12207-13.
PMID: 24161000
Thiazolino fused 2-pyridone peptidomimetics are of significant biological importance due to their ability to interfere with adhesive fiber formation in uropathogenic Escherichia coli and oligomerization of amyloid fibers. We have...