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Patrick Tschopp

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Articles 28
Citations 580
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Recent Articles
11.
Darbellay F, Bochaton C, Lopez-Delisle L, Mascrez B, Tschopp P, Delpretti S, et al.
Proc Natl Acad Sci U S A . 2019 Jun; 116(27):13424-13433. PMID: 31209053
In many animal species with a bilateral symmetry, genes are clustered either at one or at several genomic loci. This organization has a functional relevance, as the transcriptional control applied...
12.
Feregrino C, Sacher F, Parnas O, Tschopp P
BMC Genomics . 2019 May; 20(1):401. PMID: 31117954
Background: Through precise implementation of distinct cell type specification programs, differentially regulated in both space and time, complex patterns emerge during organogenesis. Thanks to its easy experimental accessibility, the developing...
13.
Marin R, Cortez D, Lamanna F, Pradeepa M, Leushkin E, Julien P, et al.
Genome Res . 2017 Nov; 27(12):1974-1987. PMID: 29133310
Sex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages. Here, we trace the functional evolution of the XY Chromosomes of the green anole lizard (), on the basis...
14.
Hiscock T, Tschopp P, Tabin C
Dev Cell . 2017 Jun; 41(5):459-465. PMID: 28586643
Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits...
15.
Tschopp P, Tabin C
Philos Trans R Soc Lond B Biol Sci . 2016 Dec; 372(1713). PMID: 27994118
The principle of homology is central to conceptualizing the comparative aspects of morphological evolution. The distinctions between homologous or non-homologous structures have become blurred, however, as modern evolutionary developmental biology...
16.
Groner A, Cato L, de Tribolet-Hardy J, Bernasocchi T, Janouskova H, Melchers D, et al.
Cancer Cell . 2016 May; 29(6):846-858. PMID: 27238081
Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-deprivation therapy is transiently effective in advanced disease, tumors often progress to a lethal castration-resistant state (CRPC)....
17.
Tschopp P, Sherratt E, Sanger T, Groner A, Aspiras A, Hu J, et al.
Nature . 2014 Nov; 516(7531):391-4. PMID: 25383527
The move of vertebrates to a terrestrial lifestyle required major adaptations in their locomotory apparatus and reproductive organs. While the fin-to-limb transition has received considerable attention, little is known about...
18.
Tschopp P, Duboule D
Methods Mol Biol . 2014 Aug; 1196:89-102. PMID: 25151159
Following their duplications at the base of the vertebrate clade, Hox gene clusters underwent remarkable sub- and neo-functionalization events. Many of these evolutionary innovations can be associated with changes in...
19.
Rohner N, Tschopp P, Tabin C
Curr Biol . 2014 Jan; 24(1):R36-R38. PMID: 24405678
A recent study in mice deciphers the complex genetic regulatory network underlying the morphogenesis of the face. The enhancer landscape underlying craniofacial development provides multiple entry points to understand what...
20.
Schorderet P, Lonfat N, Darbellay F, Tschopp P, Gitto S, Soshnikova N, et al.
PLoS Genet . 2013 Nov; 9(11):e1003951. PMID: 24244202
Polycomb group (PcG) proteins are essential for the repression of key factors during early development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined polycomb response DNA elements (PREs)....