Patrick S Covello
Overview
Explore the profile of Patrick S Covello including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
942
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Recent Articles
1.
Sasata R, Reed D, Loewen M, Covello P
J Biol Chem
. 2021 Mar;
281(25):17540.
PMID: 33725803
No abstract available.
2.
de Costa F, Barber C, Kim Y, Reed D, Zhang H, Fett-Neto A, et al.
Plant Sci
. 2017 Jul;
262:9-17.
PMID: 28716424
Triterpene saponins include bioactive compounds with structures consisting of triterpene aglycones (sapogenins) and one or more sugar moieties linked through acetal or ester glycosidic linkages at one or more sites....
3.
Dehghan E, Reed D, Covello P, Hasanpour Z, Palazon J, Oksman-Caldentey K, et al.
Plant Cell Rep
. 2017 Jul;
36(10):1615-1626.
PMID: 28707113
Tetraploidy improves overexpression of h6h and scopolamine production of H. muticus, while in H. senecionis, pmt overexpression and elicitation can be used as effective methods for increasing tropane alkaloids. The...
4.
Chekan J, Estrada P, Covello P, Nair S
Proc Natl Acad Sci U S A
. 2017 Jun;
114(25):6551-6556.
PMID: 28584123
Enzymes that can catalyze the macrocyclization of linear peptide substrates have long been sought for the production of libraries of structurally diverse scaffolds via combinatorial gene assembly as well as...
5.
de Costa F, Barber C, Pujara P, Reed D, Covello P
Methods Mol Biol
. 2016 Feb;
1405:91-7.
PMID: 26843168
Short peptide tags genetically fused to recombinant proteins have been widely used to facilitate detection or purification without the need to develop specific procedures. In general, an ideal affinity tag...
6.
de Costa F, Barber C, Reed D, Covello P
Methods Mol Biol
. 2016 Feb;
1405:43-8.
PMID: 26843164
Centella asiatica (L.) Urban (Apiaceae), a small annual plant that grows in India, Sri Lanka, Malaysia, and other parts of Asia, is well-known as a medicinal herb with a long...
7.
Kim Y, Reed D, Covello P
Nat Prod Commun
. 2016 Jan;
10(11):1919-22.
PMID: 26749827
Silene vulgaris (Moench) Garcke (Caryophyllaceae) is widely distributed in North America and contains bioactive oleanane-type saponins. In order to investigate in vitro production of triterpenoid saponins, hairy root cultures of...
8.
Dehghan E, Ahmadi F, Ghotbi Ravandi E, Reed D, Covello P, Bahrami A
Plant Physiol Biochem
. 2013 Jun;
70:188-94.
PMID: 23786817
A cDNA encoding hyoscyamine 6β-hydroxylase (H6H, EC 1.14.11.11), a bifunctional enzyme catalyzing the last two steps in the scopolamine biosynthetic pathway, was isolated from Hyoscyamus senecionis, a medicinal plant endemic...
9.
Xiao M, Zhang Y, Chen X, Lee E, Barber C, Chakrabarty R, et al.
J Biotechnol
. 2013 Apr;
166(3):122-34.
PMID: 23602801
Plants produce a vast array of specialized metabolites, many of which are used as pharmaceuticals, flavors, fragrances, and other high-value fine chemicals. However, most of these compounds occur in non-model...
10.
Barber C, Pujara P, Reed D, Chiwocha S, Zhang H, Covello P
J Biol Chem
. 2013 Mar;
288(18):12500-10.
PMID: 23486480
Caryophyllaceae-type cyclic peptides (CPs) of 5-12 proteinogenic amino acids occur in 10 plant families. In Saponaria vaccaria (Caryophyllaceae), they have been shown to be formed from linear peptide precursors derived...