Patrick S Covello
Overview
Explore the profile of Patrick S Covello including associated specialties, affiliations and a list of published articles.
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36
Citations
942
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Recent Articles
11.
Gui B, Shim Y, Datla R, Covello P, Stone S, Reaney M
J Agric Food Chem
. 2012 Aug;
60(35):8571-9.
PMID: 22897677
Cyclolinopeptides are a group of naturally occurring hydrophobic cyclic peptides found in flaxseed and flax oil that have immunosuppressive activity. This study describes the measurement of flaxseed cyclolinopeptide concentrations using...
12.
Bhar P, Reed D, Covello P, Buist P
Angew Chem Int Ed Engl
. 2012 May;
51(27):6686-90.
PMID: 22623346
No abstract available.
13.
Facchini P, Bohlmann J, Covello P, De Luca V, Mahadevan R, Page J, et al.
Trends Biotechnol
. 2012 Jan;
30(3):127-31.
PMID: 22209518
Plants display an immense diversity of specialized metabolites, many of which have been important to humanity as medicines, flavors, fragrances, pigments, insecticides and other fine chemicals. Apparently, much of the...
14.
Weathers P, Arsenault P, Covello P, McMickle A, Teoh K, Reed D
Phytochem Rev
. 2011 Jun;
10(2):173-183.
PMID: 21643453
Artemisia annua L. produces the sesquiterpene lactone, artemisinin, a potent antimalarial drug that is also effective in treating other parasitic diseases, some viral infections and various neoplasms. Artemisinin is also...
15.
Condie J, Nowak G, Reed D, Balsevich J, Reaney M, Arnison P, et al.
Plant J
. 2011 May;
67(4):682-90.
PMID: 21554452
Cyclic peptides (CPs) are produced in a very wide range of taxa. Their biosynthesis generally involves either non-ribosomal peptide synthases or ribosome-dependent production of precursor peptides. Plants within the Caryophyllaceae...
16.
Maes L, Van Nieuwerburgh F, Zhang Y, Reed D, Pollier J, Vande Casteele S, et al.
New Phytol
. 2010 Sep;
189(1):176-89.
PMID: 20874804
• Biosynthesis of the sesquiterpene lactone and potent antimalarial drug artemisinin occurs in glandular trichomes of Artemisia annua plants and is subjected to a strict network of developmental and other...
17.
Zhang Y, Nowak G, Reed D, Covello P
Plant Biotechnol J
. 2010 Aug;
9(4):445-54.
PMID: 20723135
Artemisinin, in the form of artemisinin-based combination therapies (ACTs), is currently the most important compound in the treatment of malaria. The current commercial source of artemisinin is Artemisia annua, but...
18.
Polichuk D, Zhang Y, Reed D, Schmidt J, Covello P
Phytochemistry
. 2010 Jul;
71(11-12):1264-9.
PMID: 20621795
The major components of the isoprenoid-rich essential oil of Artemisia annua L. accumulate in the subcuticular sac of glandular secretory trichomes. As part of an effort to understand isoprenoid biosynthesis...
19.
Gagne S, Reed D, Gray G, Covello P
Biochemistry
. 2009 Dec;
48(51):12298-304.
PMID: 19950909
The FAD2-like desaturases comprise a group of membrane-bound oxygenases involved in the modification of fatty acyl groups in plants and fungi. This group includes typical oleate desaturases which introduce a...
20.
Nasomjai P, Reed D, Tozer D, Peach M, Slawin A, Covello P, et al.
Chembiochem
. 2009 Aug;
10(14):2382-93.
PMID: 19693762
During the biosynthesis of certain tropane alkaloids, littorine (1) is rearranged to hyoscyamine (3). Recent evidence indicates that this isomerisation is a two-step process in which the first step is...