Patrick M Cowley
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Explore the profile of Patrick M Cowley including associated specialties, affiliations and a list of published articles.
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19
Citations
457
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Recent Articles
1.
Cowley P, Roberts C, Baker A
Comp Med
. 2019 Feb;
69(2):95-102.
PMID: 30808435
Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death...
2.
Cowley P, Wang G, Swigart P, Raghunathan A, Reddy N, Dulam P, et al.
Am J Physiol Heart Circ Physiol
. 2018 Nov;
316(1):H224-H232.
PMID: 30412439
Right ventricular (RV) failure (RVF) is a serious disease with no effective treatment available. We recently reported a disease prevention study showing that chronic stimulation of α-adrenergic receptors (α-ARs), started...
3.
Cowley P, Wang G, Joshi S, Swigart P, Lovett D, Simpson P, et al.
Am J Physiol Heart Circ Physiol
. 2017 Aug;
313(6):H1109-H1118.
PMID: 28822963
Failure of the right ventricle (RV) is a serious disease with a poor prognosis and limited treatment options. Signaling by α-adrenergic receptors (α-ARs), in particular the α-subtype, mediate cardioprotective effects...
4.
Baligand C, Qin H, True-Yasaki A, Gordon J, von Morze C, DeLos Santos J, et al.
NMR Biomed
. 2017 Jul;
30(10).
PMID: 28708304
Acute kidney injury (AKI) is a major risk factor for the development of chronic kidney disease (CKD). Persistent oxidative stress and mitochondrial dysfunction are implicated across diverse forms of AKI...
5.
Cowley P, Nair D, DeRuisseau L, Keslacy S, Atalay M, DeRuisseau K
Redox Biol
. 2017 Jul;
13:421-425.
PMID: 28697486
Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. Persons with DS exhibit pronounced muscle weakness, which also occurs in the Ts65Dn mouse model of...
6.
Ceron C, Baligand C, Joshi S, Wanga S, Cowley P, Walker J, et al.
Am J Physiol Renal Physiol
. 2017 Mar;
312(6):F1166-F1183.
PMID: 28331061
Acute kidney injury (AKI) causes severe morbidity, mortality, and chronic kidney disease (CKD). Mortality is particularly marked in the elderly and with preexisting CKD. Oxidative stress is a common theme...
7.
Myagmar B, Flynn J, Cowley P, Swigart P, Montgomery M, Thai K, et al.
Circ Res
. 2017 Feb;
120(7):1103-1115.
PMID: 28219977
Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to...
8.
Thomas Jr R, Cowley P, Singh A, Myagmar B, Swigart P, Baker A, et al.
PLoS One
. 2016 Jun;
11(6):e0155238.
PMID: 27258143
The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in...
9.
Cowley P, Wang G, Chang A, Makwana O, Swigart P, Lovett D, et al.
Am J Physiol Heart Circ Physiol
. 2015 Jun;
309(5):H888-96.
PMID: 26116709
Dysfunction of the right ventricle (RV) is closely related to prognosis for patients with RV failure. Therefore, strategies to improve failing RV function are significant. In a mouse RV failure...
10.
Chang A, Battiprolu P, Cowley P, Chen G, Gerard R, Pinto J, et al.
J Biol Chem
. 2015 Mar;
290(17):10703-16.
PMID: 25733667
In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase (cMLCK) increases Ca(2+) sensitivity of...