Paul C Simpson
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Explore the profile of Paul C Simpson including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Baker A, Li O, Jezek F, Simpson P, Chesler N, Beard D
bioRxiv
. 2025 Mar;
PMID: 40060454
New And Noteworthy: Ca is well-known to trigger activation of muscle contraction. This study demonstrates a new mechanical role for Ca in cardiac muscle involving a >6-fold increase in the...
2.
Drummond G, Natesan A, Celotto M, Shih J, Ojha P, Osako Y, et al.
bioRxiv
. 2024 Nov;
PMID: 39484425
Updating behavior based on feedback from the environment is a crucial means by which organisms learn and develop optimal behavioral strategies. Norepinephrine (NE) release from the locus coeruleus (LC) has...
3.
Lefton K, Wu Y, Yen A, Okuda T, Zhang Y, Dai Y, et al.
bioRxiv
. 2024 Jun;
PMID: 38826209
Locus coeruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling...
4.
Zhang J, Sandroni P, Huang W, Gao X, Oswalt L, Schroder M, et al.
JACC Basic Transl Sci
. 2024 Feb;
9(1):78-96.
PMID: 38362342
Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying that hazard and whether it arises from direct inhibition of cardiomyocyte...
5.
Sandroni P, Schroder M, Hawkins H, Bailon J, Huang W, Hagen J, et al.
J Mol Cell Cardiol
. 2024 Feb;
187:101-117.
PMID: 38331556
Aims: The sympathetic nervous system regulates numerous critical aspects of mitochondrial function in the heart through activation of adrenergic receptors (ARs) on cardiomyocytes. Mounting evidence suggests that α1-ARs, particularly the...
6.
Reitman M, Tse V, Mi X, Willoughby D, Peinado A, Aivazidis A, et al.
Nat Neurosci
. 2023 Mar;
26(4):579-593.
PMID: 36997759
Cortical state, defined by population-level neuronal activity patterns, determines sensory perception. While arousal-associated neuromodulators-including norepinephrine (NE)-reduce cortical synchrony, how the cortex resynchronizes remains unknown. Furthermore, general mechanisms regulating cortical synchrony...
7.
Zhang J, Simpson P, Jensen B
Am J Physiol Heart Circ Physiol
. 2020 Dec;
320(2):H725-H733.
PMID: 33275531
α1-Adrenergic receptors (ARs) are catecholamine-activated G protein-coupled receptors (GPCRs) that are expressed in mouse and human myocardium and vasculature, and play essential roles in the regulation of cardiovascular physiology. Though...
8.
Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist
Myagmar B, Ismaili T, Swigart P, Raghunathan A, Baker A, Sahdeo S, et al.
Circ Res
. 2019 Aug;
125(7):699-706.
PMID: 31426700
Rationale: Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. Objective: Test whether Gq coupling...
9.
Cowley P, Wang G, Swigart P, Raghunathan A, Reddy N, Dulam P, et al.
Am J Physiol Heart Circ Physiol
. 2018 Nov;
316(1):H224-H232.
PMID: 30412439
Right ventricular (RV) failure (RVF) is a serious disease with no effective treatment available. We recently reported a disease prevention study showing that chronic stimulation of α-adrenergic receptors (α-ARs), started...
10.
Yeh C, Fan Y, Xu Y, Yang Y, Simpson P, Mann M
PLoS One
. 2017 Dec;
12(12):e0188471.
PMID: 29216197
Rationale: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate...