Patrick H Guthrie
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Explore the profile of Patrick H Guthrie including associated specialties, affiliations and a list of published articles.
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11
Citations
439
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Recent Articles
1.
Davogustto G, Salazar R, Vasquez H, Karlstaedt A, Dillon W, Guthrie P, et al.
J Mol Cell Cardiol
. 2021 Jun;
158:115-127.
PMID: 34081952
Rationale: The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac hypertrophy. The phenotype of mTORC1 induced...
2.
Harmancey R, Vasquez H, Guthrie P, Taegtmeyer H
FASEB J
. 2013 Jul;
27(10):3966-78.
PMID: 23825227
Diabetic patients with acute myocardial infarction are more likely to die than nondiabetic patients. In the present study we examined the effect of insulin resistance on myocardial ischemia tolerance. Hearts...
3.
Harmancey R, Lam T, Lubrano G, Guthrie P, Vela D, Taegtmeyer H
FASEB J
. 2012 May;
26(8):3118-26.
PMID: 22611083
Insulin resistance is a prominent feature in heart failure, while hyperglycemia impairs cardiac contraction. We propose that decreased insulin-mediated glucose uptake by the heart preserves cardiac function in response to...
4.
Young M, Yan J, Razeghi P, Cooksey R, Guthrie P, Stepkowski S, et al.
Gene Regul Syst Bio
. 2009 Nov;
1:251-62.
PMID: 19936093
Background: During pressure overload-induced hypertrophy, unloading-induced atrophy, and diabetes mellitus, the heart induces 'fetal' genes (e.g. myosin heavy chain beta; mhc beta). Hypothesis: We propose that altered glucose homeostasis within...
5.
Essop M, Camp H, Choi C, Sharma S, Fryer R, Reinhart G, et al.
Am J Physiol Heart Circ Physiol
. 2008 May;
295(1):H256-65.
PMID: 18487439
The cardiac-enriched isoform of acetyl-CoA carboxylase (ACC2) is a key regulator of mitochondrial fatty acid (FA) uptake via carnitine palmitoyltransferase 1 (CPT1). To test the hypothesis that oxidative metabolism is...
6.
Sharma S, Guthrie P, Chan S, Haq S, Taegtmeyer H
Cardiovasc Res
. 2007 Jun;
76(1):71-80.
PMID: 17553476
Objective: Insulin regulates both glucose uptake and postnatal cardiac growth. The anabolic effects of insulin are mediated by the mammalian target of rapamycin (mTOR), an evolutionarily conserved kinase which is...
7.
Golfman L, Wilson C, Sharma S, Burgmaier M, Young M, Guthrie P, et al.
Am J Physiol Endocrinol Metab
. 2005 Mar;
289(2):E328-36.
PMID: 15797988
It is suggested that insulin resistance and metabolic maladaptation of the heart are causes of contractile dysfunction. We tested the hypothesis whether systemic PPARgamma activation, by changing the metabolic profile...
8.
Cohen D, Guthrie P, Gao X, Sakai R, Taegtmeyer H
Am J Physiol Endocrinol Metab
. 2003 Aug;
285(6):E1312-6.
PMID: 12944323
To what extent does glutamine turnover keep pace with oxidative metabolism in the rat heart? To address this question, the following groups of substrates were presented to the isolated, working...
9.
Xia Y, Wen H, Young M, Guthrie P, Taegtmeyer H, Kellems R
J Biol Chem
. 2003 Jan;
278(15):13143-50.
PMID: 12522136
The addition of glutamine as a major nutrient to cultured neonatal rat cardiomyocytes produced an increase in myocyte size and the organization of actin into myofibrillar arrays. The cellular response...
10.
Young M, Guthrie P, Razeghi P, Leighton B, Abbasi S, Patil S, et al.
Diabetes
. 2002 Jul;
51(8):2587-95.
PMID: 12145175
We investigated whether decreased responsiveness of the heart to physiological increases in fatty acid availability results in lipid accumulation and lipotoxic heart disease. Lean and obese Zucker rats were either...