Patrick Baumhof
Overview
Explore the profile of Patrick Baumhof including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
844
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0
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Recent Articles
1.
Mucker E, Thiele-Suess C, Baumhof P, Hooper J
Mol Ther Nucleic Acids
. 2022 Jun;
28:847-858.
PMID: 35664703
Poxviruses are a large and complex family of viruses with members such as monkeypox virus and variola virus. The possibility of an outbreak of monkeypox virus (or a related poxvirus)...
2.
Lindsay K, Bhosle S, Zurla C, Beyersdorf J, Rogers K, Vanover D, et al.
Nat Biomed Eng
. 2019 Apr;
3(5):371-380.
PMID: 30936432
Visualization of the spatio-temporal trafficking of vaccines after their delivery would help evaluate the efficacy of candidate formulations and aid their rational design for preclinical and translational studies. Here, we...
3.
Blanchard E, Loomis K, Bhosle S, Vanover D, Baumhof P, Pitard B, et al.
Mol Ther Nucleic Acids
. 2018 Dec;
14:52-66.
PMID: 30579042
The characterization of innate immune activation is crucial for vaccine and therapeutic development, including RNA-based vaccines, a promising approach. Current measurement methods quantify type I interferon and inflammatory cytokine production,...
4.
Bhosle S, Loomis K, Kirschman J, Blanchard E, Vanover D, Zurla C, et al.
Biomaterials
. 2018 Jan;
159:189-203.
PMID: 29331806
The translational efficiency of an in vitro transcribed (IVT) mRNA was measured upon delivery to primary skeletal muscle cells and to a mouse model system, towards the development of a...
5.
Lutz J, Lazzaro S, Habbeddine M, Schmidt K, Baumhof P, Mui B, et al.
NPJ Vaccines
. 2017 Dec;
2:29.
PMID: 29263884
mRNA represents a promising new vaccine technology platform with high flexibility in regard to development and production. Here, we demonstrate that vaccines based on sequence optimized, chemically unmodified mRNA formulated...
6.
Schnee M, Vogel A, Voss D, Petsch B, Baumhof P, Kramps T, et al.
PLoS Negl Trop Dis
. 2016 Jun;
10(6):e0004746.
PMID: 27336830
Rabies is a zoonotic infectious disease of the central nervous system (CNS). In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is invariably fatal. Despite the...
7.
Kowalczyk A, Doener F, Zanzinger K, Noth J, Baumhof P, Fotin-Mleczek M, et al.
Vaccine
. 2016 Jun;
34(33):3882-93.
PMID: 27269061
mRNA represents a new platform for the development of therapeutic and prophylactic vaccines with high flexibility with respect to production and application. We have previously shown that our two component...
8.
Thess A, Grund S, Mui B, Hope M, Baumhof P, Fotin-Mleczek M, et al.
Mol Ther
. 2015 Jun;
23(9):1456-64.
PMID: 26050989
Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe means for protein therapies. While recent findings highlight the enormous therapeutic potential of mRNA, evidence...
9.
Heidenreich R, Jasny E, Kowalczyk A, Lutz J, Probst J, Baumhof P, et al.
Int J Cancer
. 2014 Dec;
137(2):372-84.
PMID: 25530186
Protein- and peptide-based tumor vaccines depend on strong adjuvants to induce potent immune responses. Here, we demonstrated that a recently developed novel adjuvant based on a non-coding, long-chain RNA molecule,...
10.
Kallen K, Heidenreich R, Schnee M, Petsch B, Schlake T, Thess A, et al.
Hum Vaccin Immunother
. 2013 Aug;
9(10):2263-76.
PMID: 23921513
Nucleotide based vaccines represent an enticing, novel approach to vaccination. We have developed a novel immunization technology, RNActive(®) vaccines, that have two important characteristics: mRNA molecules are used whose protein...