Pasi Koskimies
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Explore the profile of Pasi Koskimies including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
205
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Recent Articles
1.
Heinosalo T, Saarinen N, Biehl A, Rytkonen K, Villa P, Juhila J, et al.
Biol Reprod
. 2024 May;
111(2):436-447.
PMID: 38780059
Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is a steroid synthetic enzyme expressed in ovarian granulosa cells and placental syncytiotrophoblasts. Here, HSD17B1 serum concentration was measured with a validated immunoassay during pregnancy...
2.
Heinosalo T, Rytkonen K, Saarinen N, Jarvensivu P, Damdimopoulou P, Strauss L, et al.
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563206
Hydroxysteroid (17beta) dehydrogenase type 1 (HSD17B1) is an enzyme that converts estrone to estradiol, while adenomyosis is an estrogen-dependent disease with poorly understood pathophysiology. In the present study, we show...
3.
Xanthoulea S, Konings G, Saarinen N, Delvoux B, Kooreman L, Koskimies P, et al.
Cancer Lett
. 2021 Mar;
508:18-29.
PMID: 33762202
Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17β-hydroxysteroid dehydrogenase...
4.
Konings G, Brentjens L, Delvoux B, Linnanen T, Cornel K, Koskimies P, et al.
Front Pharmacol
. 2018 Oct;
9:940.
PMID: 30283331
Our understanding of the intracrine (or local) regulation of estrogen and other steroid synthesis and degradation expanded in the last decades, also thanks to recent technological advances in chromatography mass-spectrometry....
5.
Konings G, Saarinen N, Delvoux B, Kooreman L, Koskimies P, Krakstad C, et al.
Int J Mol Sci
. 2018 Aug;
19(9).
PMID: 30154339
Endometrial cancer (EC) is the most common gynaecological malignancy in Western society and the majority of cases are estrogen dependent. While endocrine drugs proved to be of insufficient therapeutic value...
6.
Niinivehmas S, Postila P, Rauhamaki S, Manivannan E, Kortet S, Ahinko M, et al.
J Enzyme Inhib Med Chem
. 2018 Apr;
33(1):743-754.
PMID: 29620427
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues...
7.
Rauhamaki S, Postila P, Niinivehmas S, Kortet S, Schildt E, Pasanen M, et al.
Front Chem
. 2018 Mar;
6:41.
PMID: 29552556
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression or Parkinson's...
8.
Konings G, Cornel K, Xanthoulea S, Delvoux B, Skowron M, Kooreman L, et al.
J Pathol
. 2017 Nov;
244(2):203-214.
PMID: 29144553
The enzyme type 1 17β-hydroxysteroid dehydrogenase (17β-HSD-1), responsible for generating active 17β-estradiol (E2) from low-active estrone (E1), is overexpressed in endometrial cancer (EC), thus implicating an increased intra-tissue generation of...
9.
Uusitalo J, Turpeinen M, Tolonen A, Koskimies P, Lammintausta R, Pelkonen O
Drug Metab Pers Ther
. 2015 Nov;
31(1):35-40.
PMID: 26581074
Background: Metabolite profiles of ospemifene, a novel nonsteroidal selective estrogen receptor modulator, were surveyed as part of its development. Methods: The pharmacokinetics of ospemifene and its two major, pharmacologically active...
10.
Jarvensivu P, Saloniemi-Heinonen T, Awosanya M, Koskimies P, Saarinen N, Poutanen M
Chem Biol Interact
. 2015 Jan;
234:126-34.
PMID: 25617485
Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) belongs to a family of short-chain-dehydrogenases. The enzyme utilizes NAD(P) and NAD(P)H as cofactors, and catalyzes the reversible reaction between estrone (E1) and estradiol (E2)...