Pascual Ferrara
Overview
Explore the profile of Pascual Ferrara including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
544
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Recent Articles
1.
Diaz C, Labit-Le Bouteiller C, Yvon S, Cambon-Kerneis A, Roasio A, Jamme M, et al.
Mol Inform
. 2016 Aug;
32(2):213-29.
PMID: 27481282
The DLS-VS strategy was developed as an integrated method for identifying chemical modulators for orphan GPCRs. It combines differential low-throughput screening (DLS) and virtual screening (VS). The two cascaded techniques...
2.
Diaz C, Leplatois P, Angelloz-Nicoud P, Lecomte M, Josse A, Delpech M, et al.
Mol Inform
. 2016 Jul;
30(4):345-58.
PMID: 27466951
We discovered a constitutively activating mutation (CAM) V308E for the neurotensin NT1 receptor. Molecular dynamics (MD) performed for the CAM NT1-V308E exhibiting a high spontaneous activity, and for the wild-type...
3.
Ferrara P
Curr Pharm Biotechnol
. 2016 Mar;
17(5):471-9.
PMID: 26956112
A clear link exists between the extension of life expectancy throughout the world and the increased incidence of age-related neurodegenerative disorders. Diseases like Alzheimer's and Parkinson's are chronic diseases with...
4.
Esteve D, Boulet N, Volat F, Zakaroff-Girard A, Ledoux S, Coupaye M, et al.
Stem Cells
. 2014 Dec;
33(4):1277-91.
PMID: 25523907
Obesity-associated inflammation contributes to the development of metabolic diseases. Although brite adipocytes have been shown to ameliorate metabolic parameters in rodents, their origin and differentiation remain to be characterized in...
5.
Delcourt N, Quevedo C, Nonne C, Fons P, OBrien D, Loyaux D, et al.
J Biol Chem
. 2014 Nov;
290(6):3405-17.
PMID: 25384978
The formation of new vessels in the tumor, termed angiogenesis, is essential for primary tumor growth and facilitates tumor invasion and metastasis. Hypoxia has been described as one trigger of...
6.
Autelitano F, Loyaux D, Roudieres S, Deon C, Guette F, Fabre P, et al.
PLoS One
. 2014 Nov;
9(10):e110316.
PMID: 25360666
Glioblastoma multiform (GBM) remains clinical indication with significant "unmet medical need". Innovative new therapy to eliminate residual tumor cells and prevent tumor recurrences is critically needed for this deadly disease....
7.
O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41
Olivier-Van Stichelen S, Dehennaut V, Buzy A, Zachayus J, Guinez C, Mir A, et al.
FASEB J
. 2014 Apr;
28(8):3325-38.
PMID: 24744147
Dysfunctions in Wnt signaling increase β-catenin stability and are associated with cancers, including colorectal cancer. In addition, β-catenin degradation is decreased by nutrient-dependent O-GlcNAcylation. Human colon tumors and colons from...
8.
Conraux L, Pech C, Guerraoui H, Loyaux D, Ferrara P, Guillemot J, et al.
PLoS One
. 2013 Nov;
8(11):e79733.
PMID: 24224000
The diagnostic of Amyotrophic lateral sclerosis (ALS) remains based on clinical and neurophysiological observations. The actual delay between the onset of the symptoms and diagnosis is about 1 year, preventing...
9.
Raby A, Holst B, Le Bouder E, Diaz C, Ferran E, Conraux L, et al.
Sci Transl Med
. 2013 May;
5(185):185ra64.
PMID: 23677593
Dysregulation of Toll-like receptor (TLR) responses to pathogens can lead to pathological inflammation or to immune hyporesponsiveness and susceptibility to infections, and may affect adaptive immune responses. TLRs are therefore...
10.
GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors
Pang Z, Wu N, Zhang X, Avallone R, Croci T, Dressler H, et al.
Mol Cell Endocrinol
. 2010 Apr;
325(1-2):18-25.
PMID: 20416356
The free fatty acid (FFA) receptor GPR40, expressed by pancreatic beta-cells, may be responsible for insulin release following beta(3) adrenoceptor (Adrb3) activation. To test this hypothesis, we first studied the...