David Shire
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Explore the profile of David Shire including associated specialties, affiliations and a list of published articles.
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6
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73
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Recent Articles
1.
Trumpff C, Huang Q, Michelson J, Liu C, Shire D, Habeck C, et al.
bioRxiv
. 2025 Feb;
PMID: 39974983
Altered mitochondria biology can accelerate biological aging, but scalable biomarkers of mitochondrial health for population studies are lacking. We examined two potential candidates: 1) (cf-mtDNA), a marker of mitochondrial signaling...
2.
Huang Q, Shire D, Hollis F, Abuaish S, Picard M, Monk C, et al.
bioRxiv
. 2024 Oct;
PMID: 39464008
Objective: This study examined associations between mitochondrial markers-circulating cell-free mitochondrial DNA (cf-mtDNA) and Growth Differentiation Factor-15 (GDF15)-with maternal distress and pregnancy outcomes. Method: Participants were drawn from two pregnancy studies,...
3.
Kelly C, Trumpff C, Acosta C, Assuras S, Baker J, Basarrate S, et al.
Trends Endocrinol Metab
. 2024 Oct;
35(10):884-901.
PMID: 39389809
Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial...
4.
Devine J, Monzel A, Shire D, Rosenberg A, Junker A, Cohen A, et al.
bioRxiv
. 2024 Sep;
PMID: 39345381
Energy transformation capacity is generally assumed to be a coherent individual trait driven by genetic and environmental factors. This predicts that some individuals should have high and others low mitochondrial...
5.
Diaz C, Leplatois P, Angelloz-Nicoud P, Lecomte M, Josse A, Delpech M, et al.
Mol Inform
. 2016 Jul;
30(4):345-58.
PMID: 27466951
We discovered a constitutively activating mutation (CAM) V308E for the neurotensin NT1 receptor. Molecular dynamics (MD) performed for the CAM NT1-V308E exhibiting a high spontaneous activity, and for the wild-type...
6.
Gouldson P, Kidley N, Bywater R, Psaroudakis G, Brooks H, Diaz C, et al.
Proteins
. 2004 May;
56(1):67-84.
PMID: 15162487
Using sets of experimental distance restraints, which characterize active or inactive receptor conformations, and the X-ray crystal structure of the inactive form of bovine rhodopsin as a starting point, we...
7.
Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, et al.
Brain Res
. 2002 Oct;
953(1-2):63-72.
PMID: 12384239
Three subtypes of neurotensin receptor have been described, two members of the heptahelical transmembrane domain G protein-coupled receptor superfamily NT-1R and NT-2R, and NT-3R unrelated to this family. We have...