Pascal Mercier
Overview
Explore the profile of Pascal Mercier including associated specialties, affiliations and a list of published articles.
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30
Citations
1156
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0
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Recent Articles
1.
Li M, Mercier P, Hartman J, Sykes B
J Med Chem
. 2021 Mar;
64(6):3026-3034.
PMID: 33703886
Troponin regulates the calcium-mediated activation of skeletal muscle. Muscle weakness in diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy occurs from diminished neuromuscular output. The first direct fast...
2.
Wang Y, Tadayon R, Santamaria L, Mercier P, Forristal C, Shaw G
Biochem J
. 2021 Jan;
478(1):197-215.
PMID: 33449082
The membrane protein dysferlin (DYSF) is important for calcium-activated plasma membrane repair, especially in muscle fibre cells. Nearly 600 mutations in the DYSF gene have been identified that are causative...
3.
Gutierrez T, Qi H, Yap M, Tahbaz N, Milburn L, Lucchinetti E, et al.
Sci Signal
. 2020 Jul;
13(638).
PMID: 32606038
Chaperones in the endoplasmic reticulum (ER) control the flux of Ca ions into mitochondria, thereby increasing or decreasing the energetic output of the oxidative phosphorylation pathway. An example is the...
4.
Fu Z, Mercier P, Eskandari-Sedighi G, Yang J, Westaway D, Sykes B
Metabolomics
. 2020 Jun;
16(6):72.
PMID: 32533504
Introduction: Prion disease is a form of neurodegenerative disease caused by the misfolding and aggregation of cellular prion protein (PrP). The neurotoxicity of the misfolded form of prion protein, PrP...
5.
Dong C, Garen C, Mercier P, Petersen N, Woodside M
Protein Sci
. 2019 Jul;
28(9):1690-1702.
PMID: 31306510
Aggregation of the disordered protein α-synuclein into amyloid fibrils is a central feature of synucleinopathies, neurodegenerative disorders that include Parkinson's disease. Small, pre-fibrillar oligomers of misfolded α-synuclein are thought to...
6.
Markin C, Mercier P, Spyracopoulos L
J Phys Chem B
. 2018 Dec;
123(4):776-786.
PMID: 30590923
Cullin-RING ubiquitin ligases are a diverse family of ubiquitin ligases that catalyze the synthesis of K48-linked polyubiquitin (polyUb) chains on a variety of substrates, ultimately leading to their degradation by...
7.
Bakhtiary A, Cochrane S, Mercier P, McKay R, Miskolzie M, Sit C, et al.
J Am Chem Soc
. 2017 Nov;
139(49):17803-17810.
PMID: 29164875
Lacticin 3147 is a two peptide lantibiotc (LtnA1 and LtnA2) that displays nanomolar activity against many Gram-positive bacteria. Lacticin 3147 may exert its antimicrobial effect by several mechanisms. Isothermal titration...
8.
Aguirre J, Dunkerley K, Mercier P, Shaw G
Proc Natl Acad Sci U S A
. 2016 Dec;
114(2):298-303.
PMID: 28007983
Mutations in PARK2 and PARK6 genes are responsible for the majority of hereditary Parkinson's disease cases. These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-induced kinase...
9.
Cassiede M, Nair S, Dueck M, Mino J, McKay R, Mercier P, et al.
Data Brief
. 2016 Dec;
10:227-229.
PMID: 27995159
The data in this article are related to the research entitled, "Assessment of H NMR-based metabolomics analysis for normalization of urinary metals against creatinine" (M. Cassiède, S. Nair, M. Dueck,...
10.
Cassiede M, Nair S, Dueck M, Mino J, McKay R, Mercier P, et al.
Clin Chim Acta
. 2016 Nov;
464:37-43.
PMID: 27836686
Background: Proton nuclear magnetic resonance (H NMR, or NMR) spectroscopy and inductively coupled plasma-mass spectrometry (ICP-MS) are commonly used for metabolomics and metal analysis in urine samples. However, creatinine quantification...