Pascal Mercier
Overview
Explore the profile of Pascal Mercier including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
30
Citations
1156
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0
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Recent Articles
11.
Cochrane S, Findlay B, Bakhtiary A, Acedo J, Rodriguez-Lopez E, Mercier P, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(41):11561-11566.
PMID: 27688760
Tridecaptin A (TriA) is a nonribosomal lipopeptide with selective antimicrobial activity against Gram-negative bacteria. Here we show that TriA exerts its bactericidal effect by binding to the bacterial cell-wall precursor...
12.
Chan A, Mercier P, Schiller D, Bailey R, Robbins S, Eurich D, et al.
Br J Cancer
. 2015 Dec;
114(1):59-62.
PMID: 26645240
Background: Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and...
13.
Kumar A, Aguirre J, Condos T, Martinez-Torres R, Chaugule V, Toth R, et al.
EMBO J
. 2015 Aug;
34(20):2506-21.
PMID: 26254304
The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encodes parkin, an E3 ubiquitin ligase of the RBR family. Parkin exists in an autoinhibited...
14.
Bai J, Safadi S, Mercier P, Barber K, Shaw G
Biochemistry
. 2013 Sep;
52(42):7369-76.
PMID: 24063750
The ubiquitin signaling pathway consists of hundreds of enzymes that are tightly regulated for the maintenance of cell homeostasis. Parkin is an E3 ubiquitin ligase responsible for conjugating ubiquitin onto...
15.
Spratt D, Mercier P, Shaw G
PLoS One
. 2013 Sep;
8(8):e74047.
PMID: 24058416
The ubiquitin-signaling pathway utilizes E1 activating, E2 conjugating, and E3 ligase enzymes to sequentially transfer the small modifier protein ubiquitin to a substrate protein. During the last step of this...
16.
Spratt D, Martinez-Torres R, Noh Y, Mercier P, Manczyk N, Barber K, et al.
Nat Commun
. 2013 Jun;
4:1983.
PMID: 23770917
Mutations in the park2 gene, encoding the RING-inBetweenRING-RING E3 ubiquitin ligase parkin, cause 50% of autosomal recessive juvenile Parkinsonism cases. More than 70 known pathogenic mutations occur throughout parkin, many...
17.
Mercier P, Lewis M, Chang D, Baker D, Wishart D
J Biomol NMR
. 2011 Mar;
49(3-4):307-23.
PMID: 21360156
Nuclear magnetic resonance (NMR) and Mass Spectroscopy (MS) are the two most common spectroscopic analytical techniques employed in metabolomics. The large spectral datasets generated by NMR and MS are often...
18.
Julien O, Mercier P, Allen C, Fisette O, Ramos C, Lague P, et al.
Proteins
. 2011 Feb;
79(4):1240-50.
PMID: 21322033
In striated muscle, the binding of calcium to troponin C (TnC) results in the removal of the C-terminal region of the inhibitory protein troponin I (TnI) from actin. While structural...
19.
Julien O, Mercier P, Crane M, Sykes B
Protein Sci
. 2009 May;
18(6):1165-74.
PMID: 19472326
The unique biophysical properties of tryptophan residues have been exploited for decades to monitor protein structure and dynamics using a variety of spectroscopic techniques, such as fluorescence and nuclear magnetic...
20.
Teng R, Junankar P, Bubb W, Rae C, Mercier P, Kirk K
NMR Biomed
. 2008 Nov;
22(3):292-302.
PMID: 19021153
NMR spectroscopy was used to identify and quantify compounds in extracts prepared from mature trophozoite-stage Plasmodium falciparum parasites isolated by saponin-permeabilisation of the host erythrocyte. One-dimensional (1)H NMR spectroscopy and...