Pascal Grondin
Overview
Explore the profile of Pascal Grondin including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
491
Followers
0
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Recent Articles
1.
Karoyan P, Vieillard V, Gomez-Morales L, Odile E, Guihot A, Luyt C, et al.
Commun Biol
. 2021 Feb;
4(1):197.
PMID: 33580154
In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor...
2.
Denefle T, Pramil E, Gomez-Morales L, Levasseur M, Larde E, Newton C, et al.
J Med Chem
. 2019 Aug;
62(17):7656-7668.
PMID: 31403795
In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death of cancer cells, we designed a maturation process aimed to...
3.
Harris P, Faucher N, George N, Eidam P, King B, White G, et al.
J Med Chem
. 2019 Apr;
62(10):5096-5110.
PMID: 31013427
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have...
4.
Boufroura F, Le Bachelier C, Tomkiewicz-Raulet C, Schlemmer D, Benoist J, Grondin P, et al.
Hum Mol Genet
. 2018 Jul;
27(19):3417-3433.
PMID: 30007356
Carnitine palmitoyl transferase 2 (CPT2) deficiency is one of the most common inherited fatty acid oxidation (FAO) defects and represents a prototypical mitochondrial metabolic myopathy. Recent studies have suggested a...
5.
Woolford A, Day P, Beneton V, Berdini V, Coyle J, Dudit Y, et al.
J Med Chem
. 2016 Dec;
59(23):10738-10749.
PMID: 27933945
Lp-PLA has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype...
6.
Denefle T, Boullet H, Herbi L, Newton C, Martinez-Torres A, Guez A, et al.
J Med Chem
. 2016 Aug;
59(18):8412-21.
PMID: 27526615
Thrombospondin-1 (TSP-1) is a glycoprotein considered as a key actor within the tumor microenvironment. Its binding to CD47, a cell surface receptor, triggers programmed cell death. Previous studies allowed the...
7.
Woolford A, Pero J, Aravapalli S, Berdini V, Coyle J, Day P, et al.
J Med Chem
. 2016 May;
59(11):5356-67.
PMID: 27167608
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment...
8.
Mirguet O, Sautet S, Clement C, Toum J, Donche F, Marques C, et al.
ACS Med Chem Lett
. 2014 Jun;
4(7):632-6.
PMID: 24900722
AMP-activated protein kinase (AMPK) is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation, enhances insulin...
9.
Costell M, Ancellin N, Bernard R, Zhao S, Upson J, Morgan L, et al.
Front Pharmacol
. 2012 Jul;
3:128.
PMID: 22783192
Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of...
10.
Brusq J, Ancellin N, Grondin P, Guillard R, Martin S, Saintillan Y, et al.
J Lipid Res
. 2006 Mar;
47(6):1281-8.
PMID: 16508037
The alkaloid drug berberine (BBR) was recently described to decrease plasma cholesterol and triglycerides (TGs) in hypercholesterolemic patients by increasing expression of the hepatic low density lipoprotein receptor (LDLR). Using...