Nicolas Ancellin
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Explore the profile of Nicolas Ancellin including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
698
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Recent Articles
1.
Bhudia N, Desai S, King N, Ancellin N, Grillot D, Barnes A, et al.
Sci Rep
. 2020 Mar;
10(1):5097.
PMID: 32184438
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
2.
Bhudia N, Desai S, King N, Ancellin N, Grillot D, Barnes A, et al.
Sci Rep
. 2020 Jan;
10(1):1004.
PMID: 31969668
The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but attributing biological significance to their G protein signalling...
3.
Denefle T, Pramil E, Gomez-Morales L, Levasseur M, Larde E, Newton C, et al.
J Med Chem
. 2019 Aug;
62(17):7656-7668.
PMID: 31403795
In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death of cancer cells, we designed a maturation process aimed to...
4.
Walker A, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, et al.
J Med Chem
. 2017 Apr;
60(8):3383-3404.
PMID: 28398044
Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments...
5.
Deng H, Zhou J, Sundersingh F, Messer J, Somers D, Ajakane M, et al.
ACS Med Chem Lett
. 2016 Apr;
7(4):379-84.
PMID: 27096045
To identify BCATm inhibitors suitable for in vivo study, Encoded Library Technology (ELT) was used to affinity screen a 117 million member benzimidazole based DNA encoded library, which identified an...
6.
Borthwick J, Ancellin N, Bertrand S, Bingham R, Carter P, Chung C, et al.
J Med Chem
. 2016 Mar;
59(6):2452-67.
PMID: 26938474
Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a combination of STD-NMR, thermal melt (Tm), and biochemical assays to identify...
7.
Mole D, Webster S, Uings I, Zheng X, Binnie M, Wilson K, et al.
Nat Med
. 2016 Jan;
22(2):202-9.
PMID: 26752518
Acute pancreatitis (AP) is a common and devastating inflammatory condition of the pancreas that is considered to be a paradigm of sterile inflammation leading to systemic multiple organ dysfunction syndrome...
8.
Deng H, Zhou J, Sundersingh F, Summerfield J, Somers D, Messer J, et al.
ACS Med Chem Lett
. 2015 Aug;
6(8):919-24.
PMID: 26288694
As a potential target for obesity, human BCATm was screened against more than 14 billion DNA encoded compounds of distinct scaffolds followed by off-DNA synthesis and activity confirmation. As a...
9.
Bertrand S, Ancellin N, Beaufils B, Bingham R, Borthwick J, Boullay A, et al.
J Med Chem
. 2015 Jun;
58(18):7140-63.
PMID: 26090771
The hybridization of hits, identified by complementary fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a...
10.
Lamotte Y, Faucher N, Sancon J, Pineau O, Sautet S, Fouchet M, et al.
Bioorg Med Chem Lett
. 2014 Jan;
24(4):1098-103.
PMID: 24462665
Identification of indazole derivatives acting as dual angiotensin II type 1 (AT1) receptor antagonists and partial peroxisome proliferator-activated receptor-γ (PPARγ) agonists is described. Starting from Telmisartan, we previously described that...