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» Authors » Pascal Grondin

Pascal Grondin

Explore the profile of Pascal Grondin including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 491
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Nicolas Ancellin
Olivier Mirguet
Alain Daugan
Yannick Saintillan
Olivier Lequin
Philippe Karoyan
Florent Potvain
Lionel Trottet
Cecile Ruault
Philip J Day
Published In
J Med Chem
Front Pharmacol
Commun Biol
Diabetes
ACS Med Chem Lett
Affiliations
Soon will be listed here.
Recent Articles
11.
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, et al.
Diabetes . 2005 Apr; 54(5):1331-9. PMID: 15855317
AMP-activated protein kinase (AMPK) is a major therapeutic target for the treatment of diabetes. We investigated the effect of a short-term overexpression of AMPK specifically in the liver by adenovirus-mediated...
12.
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues
Daugan A, Grondin P, Ruault C, Le Monnier de Gouville A, Coste H, Linget J, et al.
J Med Chem . 2003 Oct; 46(21):4533-42. PMID: 14521415
Modification of the hydantoin ring in the previously described lead compound 2a has led to the discovery of compound 12a, tadalafil, a highly potent and highly selective PDE5 inhibitor. The...
13.
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues
Daugan A, Grondin P, Ruault C, Le Monnier de Gouville A, Coste H, Kirilovsky J, et al.
J Med Chem . 2003 Oct; 46(21):4525-32. PMID: 14521414
Starting from ethyl beta-carboline-3-carboxylate (beta-CCE), 1, a modest inhibitor of type 5 phosphodiesterase (PDE5), a series of functionalized tetrahydro-beta-carboline derivatives has been identified as a novel chemical class of potent...