Pascal Brouillard
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Explore the profile of Pascal Brouillard including associated specialties, affiliations and a list of published articles.
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36
Citations
671
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Recent Articles
1.
Gucciardo F, Lebeau A, Pirson S, Buntinx F, Ivanova E, Blacher S, et al.
Circulation
. 2025 Mar;
PMID: 40035133
Background: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activator...
2.
An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma
Holm A, Graus M, Wylie-Sears J, Tan J, Alvarez-Harmon M, Borgelt L, et al.
J Clin Invest
. 2025 Feb;
PMID: 39998898
Infantile hemangioma (IH) is the most common tumor in children and a paradigm for pathological vasculogenesis, angiogenesis, and regression. Propranolol, the mainstay treatment, inhibits IH vessel formation via a β-adrenergic...
3.
An endothelial SOX18-mevalonate pathway axis enables repurposing of statins for infantile hemangioma
Holm A, Graus M, Wylie-Sears J, Borgelt L, Tan J, Nasim S, et al.
bioRxiv
. 2024 Jul;
PMID: 39026886
Graphical Abstract:
4.
Brouillard P, Murtomaki A, Leppanen V, Hyytiainen M, Mestre S, Potier L, et al.
J Clin Invest
. 2024 May;
134(14).
PMID: 38820174
Primary lymphedema (PL), characterized by tissue swelling, fat accumulation, and fibrosis, results from defects in lymphatic vessels or valves caused by mutations in genes involved in development, maturation, and function...
5.
Alpaslan M, Fastre E, Mestre S, van Haeringen A, Repetto G, Keymolen K, et al.
Hum Mol Genet
. 2024 Apr;
33(14):1250-1261.
PMID: 38676400
Developmental and functional defects in the lymphatic system are responsible for primary lymphoedema (PL). PL is a chronic debilitating disease caused by increased accumulation of interstitial fluid, predisposing to inflammation,...
6.
Welsch S, Harvengt A, Gallo P, Martin M, Beckers D, Mouraux T, et al.
Diabetes Metab J
. 2024 Mar;
48(5):949-959.
PMID: 38523249
Backgruound: Recent diabetes subclassifications have improved the differentiation between patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus despite several overlapping features, yet without considering genetic forms...
7.
De Bortoli M, Queisser A, Pham V, Dompmartin A, Helaers R, Boutry S, et al.
J Invest Dermatol
. 2024 Mar;
144(9):2066-2077.e6.
PMID: 38431221
Common capillary malformations are red vascular skin lesions, most commonly associated with somatic activating GNAQ or GNA11 mutations. We focused on capillary malformations lacking such a mutation to identify previously...
8.
Seront E, Van Damme A, Legrand C, Bisdorff-Bresson A, Orcel P, Funck-Brentano T, et al.
JCI Insight
. 2023 Nov;
8(21.
PMID: 37937645
BACKGROUNDSlow-flow vascular malformations frequently harbor activating mutations in the PI3K/AKT/mTOR cascade. Phase II trials pinpointed sirolimus effectiveness as a drug therapy. Efficacy and safety of sirolimus thus need to be...
9.
Alpaslan M, Mestre-Godin S, Lay A, Giacalone G, Helaers R, Adham S, et al.
J Med Genet
. 2023 May;
60(12):1161-1168.
PMID: 37225411
Background: Primary lymphoedema (PL) is a chronic, debilitating disease caused by developmental and functional defects of the lymphatic system. It is marked by an accumulation of interstitial fluid, fat and...
10.
Cloos A, Pollet H, Stommen A, Maja M, Lingurski M, Brichard B, et al.
Blood Adv
. 2023 Feb;
7(17):4705-4720.
PMID: 36753606
Splenectomy improves the clinical parameters of patients with hereditary spherocytosis, but its potential benefit to red blood cell (RBC) functionality and the mechanism behind this benefit remain largely overlooked. Here,...