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Partha Krishnamurthy

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Articles 32
Citations 1251
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Recent Articles
1.
Qin X, Hakenjos J, MacKenzie K, Barzi M, Chavan H, Nyshadham P, et al.
Drug Metab Dispos . 2021 Nov; 50(2):128-139. PMID: 34785568
Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects...
2.
Hah J, Trafton J, Narasimhan B, Krishnamurthy P, Hilmoe H, Sharifzadeh Y, et al.
EClinicalMedicine . 2020 Dec; 28:100596. PMID: 33294812
Background: Postoperative opioid use can lead to chronic use and misuse. Few studies have examined effective approaches to taper postoperative opioid use while maintaining adequate analgesia. Methods: This randomized, assessor-blinded,...
3.
Abouleish A, Vinta S, Shabot S, Patel N, Hurwitz E, Krishnamurthy P, et al.
Perioper Med (Lond) . 2020 Dec; 9(1):34. PMID: 33292640
Background: A successful anesthesia pre-assessment clinic needs to identify patients who need further testing, evaluation, and optimization prior to the day of surgery to avoid delays and cancelations. Although the...
4.
Romman A, Doulatram G, Doctor N, Krishnamurthy P
Reg Anesth Pain Med . 2020 Feb; 45(10):763-764. PMID: 32094240
No abstract available.
5.
Agbas A, Krishnamurthy P, Michaelis M, Michaelis E
Curr Protoc Toxicol . 2019 Apr; 80(1):e73. PMID: 30951613
Measurement of the electron transfer cascade (ETC) enzyme activities and their kinetic profiles is important in assessing mitochondrial function in the nervous system in health and disease or following exposure...
6.
Wang H, Ni H, Chao X, Ma X, Rodriguez Y, Chavan H, et al.
Redox Biol . 2019 Mar; 22:101148. PMID: 30818124
Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of...
7.
Li C, He C, Xu Y, Xu H, Tang Y, Chavan H, et al.
Prostate . 2019 Jan; 79(6):628-639. PMID: 30663084
Background: Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells. Methods: To...
8.
Kumar R, Ray S, Home P, Saha B, Bhattacharya B, Wilkins H, et al.
Development . 2018 Sep; 145(19). PMID: 30201685
Early mammalian development is crucially dependent on the establishment of oxidative energy metabolism within the trophectoderm (TE) lineage. Unlike the inner cell mass, TE cells enhance ATP production via mitochondrial...
9.
Chao X, Wang S, Zhao K, Li Y, Williams J, Li T, et al.
Gastroenterology . 2018 May; 155(3):865-879.e12. PMID: 29782848
Background & Aims: Defects in lysosome function and autophagy contribute to the pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes by evaluating...
10.
Kumar D, New J, Vishwakarma V, Joshi R, Enders J, Lin F, et al.
Cancer Res . 2018 May; 78(14):3769-3782. PMID: 29769197
Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late-stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts...