Parth B Jariwala
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Explore the profile of Parth B Jariwala including associated specialties, affiliations and a list of published articles.
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10
Citations
161
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Recent Articles
1.
Graboski A, Simpson J, Pellock S, Mehta N, Creekmore B, Ariyarathna Y, et al.
RSC Chem Biol
. 2024 Aug;
5(9):853-865.
PMID: 39211470
The gut microbiome plays critical roles in human homeostasis, disease progression, and pharmacological efficacy through diverse metabolic pathways. Gut bacterial β-glucuronidase (GUS) enzymes reverse host phase 2 metabolism, in turn...
2.
Simpson J, Walker M, Sekela J, Ivey S, Jariwala P, Storch C, et al.
Cell Host Microbe
. 2024 May;
32(6):925-944.e10.
PMID: 38754417
Hormones and neurotransmitters are essential to homeostasis, and their disruptions are connected to diseases ranging from cancer to anxiety. The differential reactivation of endobiotic glucuronides by gut microbial β-glucuronidase (GUS)...
3.
Lietzan A, Simpson J, Walton W, Jariwala P, Xu Y, Boynton M, et al.
Sci Adv
. 2023 May;
9(18):eadg3390.
PMID: 37146137
Periodontitis is a chronic inflammatory disease associated with persistent oral microbial dysbiosis. The human β-glucuronidase (GUS) degrades constituents of the periodontium and is used as a biomarker for periodontitis severity....
4.
Basit A, Amory J, Mettu V, Li C, Heyward S, Jariwala P, et al.
Drug Metab Dispos
. 2023 Jan;
51(4):427-435.
PMID: 36623880
Testosterone exhibits high variability in pharmacokinetics and glucuronidation after oral administration. Although testosterone metabolism has been studied for decades, the impact of UGT2B17 gene deletion and the role of gut...
5.
Zhang J, Walker M, Sanidad K, Zhang H, Liang Y, Zhao E, et al.
Nat Commun
. 2022 Jan;
13(1):136.
PMID: 35013263
Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models. While the intestinal toxicities of TCS...
6.
Parvez M, Basit A, Jariwala P, Gaborik Z, Kis E, Heyward S, et al.
Drug Metab Dispos
. 2021 Jun;
49(8):683-693.
PMID: 34074730
The anticancer drug irinotecan shows serious dose-limiting gastrointestinal toxicity regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan disposition are known, quantitative contributions of these mechanisms in complex...
7.
Weidmann C, Mustoe A, Jariwala P, Calabrese J, Weeks K
Nat Biotechnol
. 2020 Oct;
39(3):347-356.
PMID: 33077962
RNA-protein interaction networks govern many biological processes but are difficult to examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational profiling (RNP-MaP), a live-cell chemical probing strategy that maps cooperative...
8.
Jariwala P, Pellock S, Goldfarb D, Cloer E, Artola M, Simpson J, et al.
ACS Chem Biol
. 2019 Nov;
15(1):217-225.
PMID: 31774274
It is increasingly clear that interindividual variability in human gut microbial composition contributes to differential drug responses. For example, gastrointestinal (GI) toxicity is not observed in all patients treated with...
9.
Burns J, Jariwala P, Rivera S, Fontaine B, Briggs L, Weinert E
ACS Chem Biol
. 2017 Jun;
12(8):2070-2077.
PMID: 28612602
Bacterial pathogens utilize numerous signals to identify the presence of their host and coordinate changes in gene expression that allow for infection. Within plant pathogens, these signals typically include small...
10.
Fontaine B, Nelson K, Lyles J, Jariwala P, Garcia-Rodriguez J, Quave C, et al.
Front Microbiol
. 2017 Apr;
8:496.
PMID: 28386254
is a leading cause of hospital-acquired infections. It is listed among the top "serious threats" to human health in the USA, due in large part to rising rates of resistance....