Parisa Hosseinzadeh
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Explore the profile of Parisa Hosseinzadeh including associated specialties, affiliations and a list of published articles.
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Citations
804
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Recent Articles
1.
Powers A, Renfrew P, Hosseinzadeh P, Mulligan V
bioRxiv
. 2025 Mar;
PMID: 40060652
Macrocycles are a promising therapeutic class. The incorporation of heterochiral and non-natural chemical building-blocks presents challenges for rational design, however. With no existing machine learning methods tailored for heterochiral macrocycle...
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3.
Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav K, Olive-Marti A, et al.
Nat Commun
. 2023 Dec;
14(1):8064.
PMID: 38052802
Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an...
4.
Gupta S, Azadvari N, Hosseinzadeh P
Biodes Res
. 2023 Oct;
2022:9783197.
PMID: 37850124
Recent years have witnessed a rise in methods for accurate prediction of structure and design of novel functional proteins. Design of functional protein fragments and peptides occupy a small, albeit...
5.
Barangi S, Hosseinzadeh P, Karimi G, Tayarani Najaran Z, Mehri S
Iran J Basic Med Sci
. 2023 Jul;
26(8):953-959.
PMID: 37427324
Objectives: Natural coumarin called osthole is regarded as a medicinal herb with widespread applications in Traditional Chinese Medicine. It has various pharmacological properties, including antioxidant, anti-inflammatory, and anti-apoptotic effects. In...
6.
Ray S, Gupta S, Panda G, Chatterjee P, Das A, Patawri P, et al.
J Biomol Struct Dyn
. 2023 Jul;
42(11):5502-5514.
PMID: 37409735
Breast cancer (BC) is one of the most prevalent cancers in the world and is one of the major reasons for the death of women worldwide. BC is majorly categorized...
7.
Dorogin J, Hochstatter H, Shepherd S, Svendsen J, Benz M, Powers A, et al.
Adv Healthc Mater
. 2023 Jun;
12(26):e2300793.
PMID: 37379021
Uncontrolled bone morphogenetic protein-2 (BMP-2) release can lead to off-target bone growth and other adverse events. To tackle this challenge, yeast surface display is used to identify unique BMP-2-specific protein...
8.
Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6
Watson P, Gupta S, Hosseinzadeh P, Brown B, Baker D, Christianson D
ACS Chem Biol
. 2023 Apr;
18(4):959-968.
PMID: 37027789
Histone deacetylases (HDACs) are essential for the regulation of myriad biological processes, and their aberrant function is implicated in cancer, neurodegeneration, and other diseases. The cytosolic isozyme HDAC6 is unique...
9.
Ong V, Soleimani A, Amirghasemi F, Khazaee Nejad S, Abdelmonem M, Razaviyayn M, et al.
Biosensors (Basel)
. 2023 Feb;
13(2).
PMID: 36831970
The COVID-19 pandemic revealed a pressing need for the development of sensitive and low-cost point-of-care sensors for disease diagnosis. The current standard of care for COVID-19 is quantitative reverse transcriptase...
10.
Bhardwaj G, OConnor J, Rettie S, Huang Y, Ramelot T, Mulligan V, et al.
Cell
. 2022 Aug;
185(19):3520-3532.e26.
PMID: 36041435
We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral bioavailability. We designed 184 6-12 residue macrocycles with a wide...