Nicholas M Marshall
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Explore the profile of Nicholas M Marshall including associated specialties, affiliations and a list of published articles.
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23
Citations
817
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Recent Articles
1.
Liu Y, Marshall N, Yu S, Kim W, Gao Y, Robinson H, et al.
Inorg Chem
. 2023 Jul;
62(29):11618-11625.
PMID: 37424080
In order to investigate the effects of the secondary coordination sphere in fine-tuning redox potentials (°') of type 1 blue copper (T1Cu) in cupredoxins, we have introduced M13F, M44F, and...
2.
Yu Y, Marshall N, Garner D, Nilges M, Lu Y
J Inorg Biochem
. 2022 Jun;
234:111863.
PMID: 35691263
Type 1 copper proteins have a conserved ligand set of one cysteine and two histidines, with many proteins, such as azurin, also containing an axial methionine. While the cysteine and...
3.
Benkovics T, Peng F, Phillips E, An C, Bade R, Chung C, et al.
J Am Chem Soc
. 2022 Mar;
144(13):5855-5863.
PMID: 35333525
As practitioners of organic chemistry strive to deliver efficient syntheses of the most complex natural products and drug candidates, further innovations in synthetic strategies are required to facilitate their efficient...
4.
McIntosh J, Liu Z, Andresen B, Marzijarani N, Moore J, Marshall N, et al.
Nature
. 2022 Mar;
603(7901):439-444.
PMID: 35296845
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by...
5.
Hiraga K, Mejzlik P, Marcisin M, Vostrosablin N, Gromek A, Arnold J, et al.
ACS Synth Biol
. 2021 Jan;
10(2):357-370.
PMID: 33433999
Protein engineering is the discipline of developing useful proteins for applications in research, therapeutic, and industrial processes by modification of naturally occurring proteins or by invention of proteins. Modern protein...
6.
Lee J, Der B, Karamitros C, Li W, Marshall N, Lungu O, et al.
AIChE J
. 2020 Apr;
66(3).
PMID: 32336757
We used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation....
7.
Xu Y, Verma D, Sheridan R, Liaw A, Ma J, Marshall N, et al.
J Chem Inf Model
. 2020 Apr;
60(6):2773-2790.
PMID: 32250622
Protein redesign and engineering has become an important task in pharmaceutical research and development. Recent advances in technology have enabled efficient protein redesign by mimicking natural evolutionary mutation, selection, and...
8.
Huffman M, Fryszkowska A, Alvizo O, Borra-Garske M, Campos K, Canada K, et al.
Science
. 2019 Dec;
366(6470):1255-1259.
PMID: 31806816
Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve chemical synthesis. Combining enzymatic reactions into multistep biocatalytic cascades brings additional benefits....
9.
Tian S, Liu J, Cowley R, Hosseinzadeh P, Marshall N, Yu Y, et al.
Nat Chem
. 2016 Jun;
8(7):670-7.
PMID: 27325093
S-Nitrosothiols are known as reagents for NO storage and transportation and as regulators in many physiological processes. Although the S-nitrosylation catalysed by haem proteins is well known, no direct evidence...
10.
Hosseinzadeh P, Tian S, Marshall N, Hemp J, Mullen T, Nilges M, et al.
J Am Chem Soc
. 2016 Apr;
138(20):6324-7.
PMID: 27120678
Mononuclear cupredoxin proteins usually contain a coordinately saturated type 1 copper (T1Cu) center and function exclusively as electron carriers. Here we report a cupredoxin isolated from the nitrifying archaeon Nitrosopumilus...