Timothy W Craven
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Explore the profile of Timothy W Craven including associated specialties, affiliations and a list of published articles.
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22
Citations
459
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Recent Articles
1.
Craven T, Nolan M, Bailey J, Olatunji S, Bann S, Bowen K, et al.
ACS Chem Biol
. 2024 May;
19(5):1125-1130.
PMID: 38712757
There remains a critical need for new antibiotics against multi-drug-resistant Gram-negative bacteria, a major global threat that continues to impact mortality rates. Lipoprotein signal peptidase II is an essential enzyme...
2.
Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav K, Olive-Marti A, et al.
Nat Commun
. 2023 Dec;
14(1):8064.
PMID: 38052802
Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an...
3.
Li X, Craven T, Levine P
J Med Chem
. 2022 Sep;
65(18):11913-11926.
PMID: 36074956
Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the...
4.
Bhardwaj G, OConnor J, Rettie S, Huang Y, Ramelot T, Mulligan V, et al.
Cell
. 2022 Aug;
185(19):3520-3532.e26.
PMID: 36041435
We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral bioavailability. We designed 184 6-12 residue macrocycles with a wide...
5.
Levine P, Craven T, Li X, Balana A, Bird G, Godes M, et al.
ACS Chem Biol
. 2022 Mar;
17(4):804-809.
PMID: 35319882
Peptide and protein bioconjugation technologies have revolutionized our ability to site-specifically or chemoselectively install a variety of functional groups for applications in chemical biology and medicine, including the enhancement of...
6.
Stone E, Hosseinzadeh P, Craven T, Robertson M, Han Y, Hsieh S, et al.
ACS Catal
. 2021 Oct;
11(8):4395-4400.
PMID: 34659874
Studying the relationship between catalyst conformational dynamics and selectivity in an asymmetric reaction is a challenge. In this study, cyclic peptides were computationally designed to stabilize different ground state conformations...
7.
Hosseinzadeh P, Watson P, Craven T, Li X, Rettie S, Pardo-Avila F, et al.
Nat Commun
. 2021 Jun;
12(1):3384.
PMID: 34099674
Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we...
8.
Balana A, Levine P, Craven T, Mukherjee S, Pedowitz N, Moon S, et al.
Nat Chem
. 2021 Mar;
13(5):441-450.
PMID: 33723378
A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area focused on O-GlcNAc modification of...
9.
Mulligan V, Workman S, Sun T, Rettie S, Li X, Worrall L, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(12).
PMID: 33723038
The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades β-lactam antibiotics. We present structure-guided...
10.
Mulligan V, Kang C, Sawaya M, Rettie S, Li X, Antselovich I, et al.
Protein Sci
. 2020 Oct;
29(12):2433-2445.
PMID: 33058266
Cyclic symmetry is frequent in protein and peptide homo-oligomers, but extremely rare within a single chain, as it is not compatible with free N- and C-termini. Here we describe the...