Parirokh Awasthi
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Explore the profile of Parirokh Awasthi including associated specialties, affiliations and a list of published articles.
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19
Citations
587
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Recent Articles
11.
Ohigashi I, Frantzeskakis M, Jacques A, Fujimori S, Ushio A, Yamashita F, et al.
J Exp Med
. 2021 Feb;
218(4).
PMID: 33555295
The thymoproteasome expressed specifically in thymic cortical epithelium optimizes the generation of CD8+ T cells; however, how the thymoproteasome contributes to CD8+ T cell development is unclear. Here, we show...
12.
Harly C, Kenney D, Wang Y, Ding Y, Zhao Y, Awasthi P, et al.
Front Immunol
. 2020 Apr;
11:470.
PMID: 32265924
The transcription factor TCF-1 (encoded by ) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for regulation in T cells, innate...
13.
Yuan Y, Park J, Feng A, Awasthi P, Wang Z, Chen Q, et al.
Nat Commun
. 2020 Mar;
11(1):1472.
PMID: 32193376
The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstream gene networks involved in their activity are not completely understood. Here...
14.
Larsen B, Cowan J, Wang Y, Tanaka Y, Zhao Y, Voisin B, et al.
J Immunol
. 2019 Jun;
203(3):686-695.
PMID: 31243087
The thymus is critical for the establishment of the adaptive immune system and the development of a diverse T cell repertoire. T cell development depends upon cell-cell interactions with epithelial...
15.
Yohe M, Gryder B, Shern J, Song Y, Chou H, Sindiri S, et al.
Sci Transl Med
. 2018 Jul;
10(448).
PMID: 29973406
The RAS isoforms are frequently mutated in many types of human cancers, including PAX3/PAX7 fusion-negative rhabdomyosarcoma. Pediatric RMS arises from skeletal muscle progenitor cells that have failed to differentiate normally....
16.
Jiang J, Promchan K, Jiang H, Awasthi P, Marshall H, Harned A, et al.
J Genet Genomics
. 2016 Jun;
43(6):381-91.
PMID: 27312011
Bardet-Biedl syndrome (BBS) is a heterogeneous disease characterized by deficiencies in various organs that are caused by defects in genes involved in the genesis, structural maintenance, and protein trafficking of...
17.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon K, Resch W, et al.
Cell
. 2014 Dec;
159(7):1524-37.
PMID: 25483777
The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study...
18.
Chen J, Feigenbaum L, Awasthi P, Butcher D, Anver M, Golubeva Y, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(33):13534-9.
PMID: 23904478
Increased serum levels of IL-15 are reported in type 1 diabetes (T1D). Here we report elevated serum soluble IL-15Rα levels in human T1D. To investigate the role of IL-15/IL-15Rα in...
19.
Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon K, Bandle R, et al.
Cell
. 2013 May;
153(5):988-99.
PMID: 23706737
Lymphocyte activation is initiated by a global increase in messenger RNA synthesis. However, the mechanisms driving transcriptome amplification during the immune response are unknown. By monitoring single-stranded DNA genome wide,...
20.
Young M, Farrell L, Lambert P, Awasthi P, Colburn N
Mol Carcinog
. 2002 Jul;
34(2):72-7.
PMID: 12112313
Expression of the human papillomavirus (HPV) type 16 E6 and E7 gene products is a risk factor for human cervical carcinogenesis as well as skin and oral carcinogenesis. Expression of...