Pedro P Rocha
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Explore the profile of Pedro P Rocha including associated specialties, affiliations and a list of published articles.
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37
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1368
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Recent Articles
1.
Chakraborty S, Wenzlitschke N, Anderson M, Eraso A, Baudic M, Thompson J, et al.
Dev Cell
. 2025 Feb;
PMID: 40015278
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysregulation and phenotypes. We tested whether perturbing a...
2.
Chakraborty S, Wenzlitschke N, Anderson M, Eraso A, Baudic M, Thompson J, et al.
bioRxiv
. 2024 Oct;
PMID: 39372737
Chromatin domain boundaries delimited by CTCF motifs can restrict the range of enhancer action. However, disruption of domain structure often results in mild gene dysregulation and thus predicting the impact...
3.
Brown J, Zhang L, Rocha P, Kassis J, Sun M
Sci Adv
. 2024 Apr;
10(17):eadn1837.
PMID: 38657072
Polycomb group (PcG) proteins mediate epigenetic silencing of important developmental genes by modifying histones and compacting chromatin through two major protein complexes, PRC1 and PRC2. These complexes are recruited to...
4.
Rhodes C, Asokumar D, Sohn M, Naskar S, Elisha L, Stevenson P, et al.
Front Cell Neurosci
. 2024 Feb;
18:1334244.
PMID: 38419656
Introduction: Enhancer of zeste homolog 2 (Ezh2) is responsible for trimethylation of histone 3 at lysine 27 (H3K27me3), resulting in repression of gene expression. Here, we explore the role of...
5.
Brown J, Zhang L, Rocha P, Kassis J, Sun M
bioRxiv
. 2023 Dec;
PMID: 38076900
Polycomb group proteins (PcG) mediate epigenetic silencing of important developmental genes and other targets. In Drosophila, canonical PcG-target genes contain Polycomb Response Elements (PREs) that recruit PcG protein complexes including...
6.
Xie G, Lee J, Senft A, Park Y, Jang Y, Chakraborty S, et al.
Nat Genet
. 2023 Apr;
55(4):693-705.
PMID: 37012455
H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4 enzymatic activities and MLL3/4-mediated enhancer H3K4me1 in these processes remain...
7.
Chakraborty S, Kopitchinski N, Zuo Z, Eraso A, Awasthi P, Chari R, et al.
Nat Genet
. 2023 Jan;
55(2):280-290.
PMID: 36717694
How enhancers activate their distal target promoters remains incompletely understood. Here we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions. Using an allelic series of mouse mutants, we...
8.
Lancho O, Singh A, da Silva-Diz V, Aleksandrova M, Khatun J, Tottone L, et al.
Blood Cancer Discov
. 2022 Nov;
4(1):12-33.
PMID: 36322781
Significance: We identify a T-ALL axis whereby NOTCH1 activates SIRT1 through an enhancer region, and SIRT1 deacetylates and activates KAT7. Targeting SIRT1 shows antileukemic effects, partly mediated by KAT7 inactivation....
9.
Kurotaki D, Kikuchi K, Cui K, Kawase W, Saeki K, Fukumoto J, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(34):e2207009119.
PMID: 35969760
Classical dendritic cells (cDCs) are essential for immune responses and differentiate from hematopoietic stem cells via intermediate progenitors, such as monocyte-DC progenitors (MDPs) and common DC progenitors (CDPs). Upon infection,...
10.
Thompson J, Lee D, Mitra A, Frail S, Dale R, Rocha P
Nat Commun
. 2022 Jul;
13(1):4257.
PMID: 35871075
Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co-expresses the TFs NANOG and GATA6, which drive the...