Parirokh Awasthi
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Explore the profile of Parirokh Awasthi including associated specialties, affiliations and a list of published articles.
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19
Citations
587
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Recent Articles
1.
Chakraborty S, Wenzlitschke N, Anderson M, Eraso A, Baudic M, Thompson J, et al.
Dev Cell
. 2025 Feb;
PMID: 40015278
Chromatin domains delimited by CTCF can restrict the range of enhancer action. However, disruption of some domain boundaries results in mild gene dysregulation and phenotypes. We tested whether perturbing a...
2.
Verma A, Aylward B, Ma F, Sherman C, Chopp L, Shinton S, et al.
Sci Adv
. 2024 Nov;
10(48):eado5982.
PMID: 39602533
Loss-of-function studies have shown that transcription factor T cell factor-1 (TCF1), encoded by the gene, is essential for T cell development in the thymus. We discovered that the expression level...
3.
Chakraborty S, Wenzlitschke N, Anderson M, Eraso A, Baudic M, Thompson J, et al.
bioRxiv
. 2024 Oct;
PMID: 39372737
Chromatin domain boundaries delimited by CTCF motifs can restrict the range of enhancer action. However, disruption of domain structure often results in mild gene dysregulation and thus predicting the impact...
4.
Das A, Martinez-Ruiz G, Bouladoux N, Stacy A, Moraly J, Vega-Sendino M, et al.
Immunity
. 2024 Apr;
57(5):1019-1036.e9.
PMID: 38677292
Group 3 innate lymphoid cells (ILC3) are the major subset of gut-resident ILC with essential roles in infections and tissue repair, but how they adapt to the gut environment to...
5.
Sala L, Kumar M, Prajapat M, Chandrasekhar S, Cosby R, La Rocca G, et al.
Nat Struct Mol Biol
. 2023 Nov;
30(12):1985-1995.
PMID: 37985687
Argonaute 2 (AGO2) is a cytoplasmic component of the miRNA pathway, with essential roles in development and disease. Yet little is known about its regulation in vivo. Here we show...
6.
Chakraborty S, Kopitchinski N, Zuo Z, Eraso A, Awasthi P, Chari R, et al.
Nat Genet
. 2023 Jan;
55(2):280-290.
PMID: 36717694
How enhancers activate their distal target promoters remains incompletely understood. Here we dissect how CTCF-mediated loops facilitate and restrict such regulatory interactions. Using an allelic series of mouse mutants, we...
7.
Hebron K, Wan X, Roth J, Liewehr D, Sealover N, Frye W, et al.
Clin Cancer Res
. 2022 Nov;
29(2):472-487.
PMID: 36322002
Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also...
8.
Li C, Kim H, Prakhar P, Luo S, Crossman A, Ligons D, et al.
Mucosal Immunol
. 2022 Jul;
15(5):882-895.
PMID: 35778600
The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small intestine (SI). Notably, CCR9...
9.
Won H, Kim H, Crossman A, Awasthi P, Gress R, Park J
Front Immunol
. 2021 May;
12:642856.
PMID: 34054809
Invariant NKT (NKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature NKT cells...
10.
Huang Q, Li W, Zhou Q, Awasthi P, Cazin C, Yap Y, et al.
Dev Biol
. 2021 May;
477:164-176.
PMID: 34023333
Intraflagellar transport (IFT) is an evolutionarily conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella, including mammalian sperm tails. Depletion of IFT27, a component of...