Parameswaran Ramachandran
Overview
Explore the profile of Parameswaran Ramachandran including associated specialties, affiliations and a list of published articles.
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20
Citations
377
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Recent Articles
1.
Nechanitzky R, Ramachandran P, Nechanitzky D, Li W, Wakeham A, Haight J, et al.
Cell Death Differ
. 2024 Feb;
31(3):265-279.
PMID: 38383888
PirB is an inhibitory cell surface receptor particularly prominent on myeloid cells. PirB curtails the phenotypes of activated macrophages during inflammation or tumorigenesis, but its functions in macrophage homeostasis are...
2.
Fortin J, Chiang M, Meydan C, Foox J, Ramachandran P, Leca J, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2208176120.
PMID: 36652477
Mutations in , and are recurrently observed in myeloid neoplasms. and encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic mutations confer neomorphic activity,...
3.
Nechanitzky R, Nechanitzky D, Ramachandran P, Duncan G, Zheng C, Gobl C, et al.
Cell Death Differ
. 2022 Dec;
30(2):407-416.
PMID: 36528755
Experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis (MS) in which Th17 cells have a crucial but unclear function. Here we show that choline acetyltransferase (ChAT), which...
4.
Kubli S, Ramachandran P, Duncan G, Brokx R, Mak T
Nat Commun
. 2022 Jul;
13(1):3950.
PMID: 35817786
No abstract available.
5.
Dick S, Wong A, Hamidzada H, Nejat S, Nechanitzky R, Vohra S, et al.
Sci Immunol
. 2022 Jan;
7(67):eabf7777.
PMID: 34995099
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual tissues contain heterogeneous subpopulations, and how these subpopulations are related...
6.
Fortin J, Bassi C, Ramachandran P, Li W, Tian R, Zarrabi I, et al.
J Clin Invest
. 2021 Jan;
131(5).
PMID: 33444287
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting...
7.
Fortin J, Tian R, Zarrabi I, Hill G, Williams E, Sanchez-Duffhues G, et al.
Cancer Cell
. 2020 Mar;
37(3):308-323.e12.
PMID: 32142668
Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone...
8.
Kubli S, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, et al.
Nat Commun
. 2019 Sep;
10(1):4069.
PMID: 31481706
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Kubli S, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, et al.
Nat Commun
. 2019 Jun;
10(1):2678.
PMID: 31213601
Myeloid cells contribute to tumor progression, but how the constellation of receptors they express regulates their functions within the tumor microenvironment (TME) is unclear. We demonstrate that Fcmr (Toso), the...
10.
Kubli S, Bassi C, Roux C, Wakeham A, Gobl C, Zhou W, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(9):3604-3613.
PMID: 30733286
Cancer cells have higher reactive oxygen species (ROS) than normal cells, due to genetic and metabolic alterations. An emerging scenario is that cancer cells increase ROS to activate protumorigenic signaling...