Par Nordlund
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Explore the profile of Par Nordlund including associated specialties, affiliations and a list of published articles.
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136
Citations
6332
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Recent Articles
11.
Ceder S, Eriksson S, Liang Y, Cheteh E, Zhang S, Fujihara K, et al.
Cell Death Dis
. 2021 Jul;
12(7):709.
PMID: 34267184
Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been...
12.
Liang Y, Bacanu S, Sreekumar L, Ramos A, Dai L, Michaelis M, et al.
Cell Chem Biol
. 2021 Jul;
29(4):572-585.e8.
PMID: 34265272
The optimal use of many cancer drugs is hampered by a lack of detailed understanding of their mechanism of action (MoA). Here, we apply a high-resolution implementation of the proteome-wide...
13.
Sun J, Prabhu N, Tang J, Yang F, Jia L, Guo J, et al.
Med Res Rev
. 2021 Feb;
41(6):2893-2926.
PMID: 33533067
Small-molecule drugs modulate biological processes and disease states through engagement of target proteins in cells. Assessing drug-target engagement on a proteome-wide scale is of utmost importance in better understanding the...
14.
Dai L, Li Z, Chen D, Jia L, Guo J, Zhao T, et al.
Pharmacol Ther
. 2020 Sep;
216:107690.
PMID: 32980441
Natural products (NPs) have been an important source of therapeutic drugs in clinic use and contributed many chemical probes for research. The usefulness of NPs is however often marred by...
15.
Dziekan J, Wirjanata G, Dai L, Go K, Yu H, Lim Y, et al.
Nat Protoc
. 2020 Apr;
15(6):1881-1921.
PMID: 32341577
Despite decades of research, little is known about the cellular targets and the mode of action of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal...
16.
Mahony C, Ashton R, Birk B, Boobis A, Cull T, Daston G, et al.
Regul Toxicol Pharmacol
. 2020 Apr;
114:104668.
PMID: 32335207
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a 'Blue Sky Workshop' on new ideas for non-animal approaches to predict repeated-dose systemic toxicity. The aim of the...
17.
Langeback A, Bacanu S, Laursen H, Mout L, Seki T, Erkens-Schulze S, et al.
Sci Rep
. 2019 Dec;
9(1):19384.
PMID: 31852908
The use of taxanes has for decades been crucial for treatment of several cancers. A major limitation of these therapies is inherent or acquired drug resistance. A key to improved...
18.
Prabhu N, Dai L, Nordlund P
Curr Opin Chem Biol
. 2019 Dec;
54:54-62.
PMID: 31838273
The Cellular Thermal Shift Assay (CETSA) has recently emerged as a promising method to directly monitor functional modulations of protein interaction states in intact cells and tissue samples. Recent data...
19.
Asial I, Nordlund P, Dahlroth S
Methods Mol Biol
. 2019 Jul;
2025:299-320.
PMID: 31267459
Highly soluble and stable proteins are desirable for many different applications, from basic science to reaching a cancer patient in the form of a biological drug. For X-ray crystallography-where production...
20.
Dai L, Prabhu N, Yu L, Bacanu S, Ramos A, Nordlund P
Annu Rev Biochem
. 2019 Apr;
88:383-408.
PMID: 30939043
The cellular thermal shift assay (CETSA) is a biophysical technique allowing direct studies of ligand binding to proteins in cells and tissues. The proteome-wide implementation of CETSA with mass spectrometry...