Lionel Tresaugues
Overview
Explore the profile of Lionel Tresaugues including associated specialties, affiliations and a list of published articles.
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26
Citations
666
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Recent Articles
1.
Yu Y, Bogdan M, Noman M, Parpal S, Bartolini E, Van Moer K, et al.
Mol Oncol
. 2024 Mar;
18(8):1904-1922.
PMID: 38506049
An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting...
2.
Thorsell A, Ekblad T, Karlberg T, Low M, Pinto A, Tresaugues L, et al.
J Med Chem
. 2019 Jun;
62(12):5922.
PMID: 31242737
No abstract available.
3.
Rahm F, Viklund J, Tresaugues L, Ellermann M, Giese A, Ericsson U, et al.
J Med Chem
. 2018 Feb;
61(6):2533-2551.
PMID: 29485874
Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for assessing the effects of pharmacological...
4.
Stafford W, Peng X, Olofsson M, Zhang X, Luci D, Lu L, et al.
Sci Transl Med
. 2018 Feb;
10(428).
PMID: 29444979
Cancer cells adapt to their inherently increased oxidative stress through activation of the glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems effectively kills cancer cells, but...
5.
Ellermann M, Eheim A, Rahm F, Viklund J, Guenther J, Andersson M, et al.
ACS Chem Biol
. 2017 Jul;
12(8):1986-1992.
PMID: 28679043
MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool compounds published in the literature inhibited the enzymatic activity...
6.
Thorsell A, Ekblad T, Karlberg T, Low M, Pinto A, Tresaugues L, et al.
J Med Chem
. 2016 Dec;
60(4):1262-1271.
PMID: 28001384
Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research...
7.
Mills S, Silvander C, Cozier G, Tresaugues L, Nordlund P, Potter B
Biochemistry
. 2016 Feb;
55(9):1384-97.
PMID: 26854536
The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups,...
8.
Lim S, Yeung K, Tresaugues L, Ling T, Nordlund P
FEBS J
. 2016 Jan;
283(6):1107-23.
PMID: 26783088
Unlabelled: Human sphingomyelinase phosphodiesterase like 3a (SMPDL3a) is a secreted enzyme that shares a conserved catalytic domain with human acid sphingomyelinase (aSMase), the enzyme carrying mutations causative of Niemann-Pick disease....
9.
Tresaugues L, Lundback T, Welin M, Flodin S, Nyman T, Silvander C, et al.
PLoS One
. 2015 Jun;
10(6):e0131507.
PMID: 26121039
Human NUDT16 is a member of the NUDIX hydrolase superfamily. After having been initially described as an mRNA decapping enzyme, recent studies conferred it a role as an "housecleaning" enzyme...
10.
Tresaugues L, Silvander C, Flodin S, Welin M, Nyman T, Graslund S, et al.
Structure
. 2014 Apr;
22(5):744-55.
PMID: 24704254
SHIP2, OCRL, and INPP5B belong to inositol polyphosphate 5-phophatase subfamilies involved in insulin regulation and Lowes syndrome. The structural basis for membrane recognition, substrate specificity, and regulation of inositol polyphosphate ...