Paolo S Manzanillo
Overview
Explore the profile of Paolo S Manzanillo including associated specialties, affiliations and a list of published articles.
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8
Citations
1193
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Recent Articles
1.
Lau L, Cariaga T, Chang A, Lane J, Purtha W, Rapaport A, et al.
Nat Commun
. 2025 Jan;
16(1):968.
PMID: 39856038
TASL is an immune adaptor that binds to the solute carrier SLC15A4 and facilitates activation of the transcription factor IRF5 during Toll-like receptor (TLR) signaling. Similar to IRF5 and SLC15A4,...
2.
Bhatt D, Kang B, Sawant D, Zheng L, Perez K, Huang Z, et al.
J Exp Med
. 2021 Apr;
218(6).
PMID: 33900375
Single-cell RNA sequencing is a powerful tool to examine cellular heterogeneity, novel markers and target genes, and therapeutic mechanisms in human cancers and animal models. Here, we analyzed single-cell RNA...
3.
Hao Y, Purtha W, Cortesio C, Rui H, Gu Y, Chen H, et al.
PLoS One
. 2019 Jun;
14(6):e0218063.
PMID: 31181113
[This corrects the article DOI: 10.1371/journal.pone.0200374.].
4.
Alumasa J, Manzanillo P, Peterson N, Lundrigan T, Baughn A, Cox J, et al.
ACS Infect Dis
. 2017 Aug;
3(9):634-644.
PMID: 28762275
The emergence of Mycobacterium tuberculosis (MTB) strains that are resistant to most or all available antibiotics has created a severe problem for treating tuberculosis and has spurred a quest for...
5.
Zacharia V, Manzanillo P, Nair V, Marciano D, Kinch L, Grishin N, et al.
mBio
. 2013 Nov;
4(6):e00721-13.
PMID: 24255121
Unlabelled: Tuberculosis, caused by Mycobacterium tuberculosis, remains a devastating human infectious disease, causing two million deaths annually. We previously demonstrated that M. tuberculosis induces an enzyme, heme oxygenase (HO1), that...
6.
Manzanillo P, Ayres J, Watson R, Collins A, Souza G, Rae C, et al.
Nature
. 2013 Sep;
501(7468):512-6.
PMID: 24005326
Ubiquitin-mediated targeting of intracellular bacteria to the autophagy pathway is a key innate defence mechanism against invading microbes, including the important human pathogen Mycobacterium tuberculosis. However, the ubiquitin ligases responsible...
7.
Eisele N, Ruby T, Jacobson A, Manzanillo P, Cox J, Lam L, et al.
Cell Host Microbe
. 2013 Aug;
14(2):171-182.
PMID: 23954156
Host-adapted Salmonella strains are responsible for a number of disease manifestations in mammals, including an asymptomatic chronic infection in which bacteria survive within macrophages located in systemic sites. However, the...
8.
Watson R, Manzanillo P, Cox J
Cell
. 2012 Aug;
150(4):803-15.
PMID: 22901810
Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can...
9.
Manzanillo P, Shiloh M, Portnoy D, Cox J
Cell Host Microbe
. 2012 May;
11(5):469-80.
PMID: 22607800
Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium tuberculosis is poorly understood. We show that...